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Scientist I/II/Senior Scientist Organic Chemistry

Ambrx, Inc.
La Jolla, CA
$82,000- $125,000
Start date
Nov 29, 2023

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Science/R&D, Biotechnology, Chemistry
Required Education
Masters Degree/MBA
Position Type
Full time
Biotech Beach

Job Details

What We Do:

Ambrx Biopharma, Inc. is a clinical-stage biologics company focused on discovering and developing a novel class of specific and selective engineered precision biologics, using our proprietary platform technology that allows site-specific incorporation of synthetic amino acids (SAAs) into proteins within living cells. Our product candidates are designed to overcome the inherent limitations of conventional conjugation approaches that use non-site-specific conjugation, in order to optimize for safety and efficacy benefits across multiple therapeutic classes in broad therapeutic areas.

How will you contribute to our mission:


  • The successful candidate will support our small molecule synthesis and carryout analytical and preparative method development to support needs as necessary.
  • Interpret experimental results such as in vitro/in vivo data to support new compound design and carryout structure-activity relationship studies delivering high quality material for biological testing.
  • Collaborate and interface with other functional teams including analytical, biology and pharmacology to facilitate development and execution of project plans.
  • Communicate research findings to the key stake holders and present in project meetings/conferences.
  • Contribute to patent application writing and research reports.
  • Support identify and establish working relationships with CROs and manage external chemistry resources.
  • Safe keeping and operation of lab and lab equipment.
What you will need for consideration:
  • MS or Ph.D degree in organic/medicinal chemistry or related field with 3-10 years of post-doctoral and industry experience.
  • Well versed in modern synthetic organic chemistry techniques, designing new synthetic routes for complex molecules, and carrying out multi-step synthesis of biologically active molecules.
  • Hands-on experience with analytical and purification equipment HPLC, LC-MS and NMR etc.
  • Experience working with ADC, peptide, polymer, and protein chemical modification is a plus.
  • Excellent communication, organizational and collaborative skills are essential.


Pay Scale:

The pay scale for this position is: $82,000- $125,000 commensurate with experience. We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.

As an equal opportunity employer, Ambrx is committed to a diverse workforce. Ambrx will consider all qualified applicants without regard to race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws.





Ambrx®, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics using an expanded genetic code. Unlike conventional conjugation techniques that create a mixture of suboptimal molecules, Ambrx technology combines site specific conjugation with proprietary linkers, payloads and pharmacokinetic extenders to create a single molecular species that is optimized for safety, efficacy and biophysical properties. We call this process Protein Medicinal Chemistry™.

Protein Medicinal Chemistry™ can optimize any protein or antibody to create potentially best-in-class therapeutics such as long-acting proteins, bi-specifics and antibody drug conjugates. The Ambrx advantage allows us to safely and effectively target cytotoxic agents or recruit effector function to tumor cells (oncology) or modulate biological pathways implicated in disease areas such as autoimmune, metabolic and cardiovascular.

At Ambrx, we are dedicated to assembling and developing an exceptional team and a novel technology to create the next generation of protein-based medicines.

Company info
10975 North Torrey Pines Road
La Jolla
United States

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