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Senior Scientist, Cell Therapy Process Research & Engineering

Employer
Bristol Myers Squibb Company
Location
Seattle, Washington
Start date
Nov 28, 2023

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Job Details

Working with Us
Challenging. Meaningful. Life-changing. Those arent words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. Youll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Cancer Immunology and Cellular Therapy Thematic Research Center is one of the fundamental research and early development engines delivering therapeutics to patients. Our mission is to drive leadership in the use of immune effector cell-based therapies in hematological and solid cancers. More specifically, we are focused on developing engineered cell-based therapies, as well as biotherapeutics, both aimed at harnessing the power of immune cells to mediate anti-tumor activity. The team integrates discovery research seamlessly with preclinical sciences, translational research, early clinical development and process development in collaboration with colleagues across the Research and Development organizations. The team works at the exciting interface of engineered T-cell biology and cell therapy process development, with the goal of advancing novel innovative platforms from early concept design towards implementation for pipeline assets. Our thematic focus allows the group to capitalize on the cutting-edge science that underpins the action of many of the companys most innovative therapeutics, without being constrained by drug modality or disease indication. Here, youll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. Youll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

The Cell Therapy Process Research and Engineering (CT-PRE) team is seeking a highly motivated, dynamic, self-driven and collaborative individual to contribute to the exploration and early process development of new R&ED cell therapy projects. In the Sr. Scientist role, the successful candidate will focus on developing a clinically scalable gene editing process, integrating it with upstream and downstream technologies to build an early prototype end-to-end process. The candidate will collaborate cross-functionally to assess the impact of process changes on product characteristics, function and manufacturability. In addition, the candidate will also be contributing to the exploration and inclusion of new technologies and strategies for next-generation cell therapy products and processes.

The ideal candidate will have a strong understanding of T cell biology and cancer immunology, a solid grasp on gene editing techniques, prior experience with and understanding of key challenges related to the scaling up and implementation of gene editing and delivery technologies, and a strong background in process and technology development. This role will provide a challenging but rewarding opportunity for career development in a fast-paced environment and is ideal for a scientist with an innovative cell engineering mindset. A previous experience in cellular therapy, industry or academic, is preferred.

Position Responsibilities:

In the role as a Senior Scientist, the ideal candidate:

  • Applies scientific and / or technical skills and functional knowledge to design and conduct experiments and research projects pertaining to viral and non-viral based cell therapy engineering.

  • Adapts gene editing and delivery methods and cell processing technologies by applying breadth of knowledge and prior work experience.

  • Evaluates at-scale feasibility/performances of research-scale proof-of-concepts and provides inputs on manufacturability success.

  • Works to develop clinical/manufacturing scale processes and build early process understanding, in close collaboration with colleagues in the Development and Research organizations.

  • Applies statistical experimental design frameworks (e.g. DoE) to conduct studies exploring a large multi-factorial design space.

  • Designs rational experiments to identify and analyse functional implications and T-cell biology impact of changes made to the manufacturing process.

  • Works with other team members to develop and evaluate technical feasibility of novel gene editing and delivery methods.

  • Leads discussions and makes presentations in multidisciplinary meetings, logically presenting information to convey clear, key messages.

  • Works proactively to engage all stakeholders cross-functionally to collect inputs and feedback.

Basic Qualifications:

  • Bachelors Degree

    • 7+ years of academic and / or industry experience

Or

  • Masters Degree

    • 5+ years of academic and / or industry experience

Or

  • Ph.D. or equivalent advanced degree in the Life Sciences

    • 2+ of academic and / or industry experience

Preferred Qualifications:

  • Background in molecular immunology is a plus.

  • Hands-on experience with gene editing technologies (CRISPR-based preferred), using viral and non-viral (electroporation, lipid nanoparticles, etc.) delivery mechanisms in primary cells, particularly immune cells.

  • Hands-on experience (preferred) or familiarity working with at-scale cell processing technology and instrumentation.

  • Experience in both research scale and clinical manufacturing scale processes for unit operations on gene delivery and editing, activation and expansion of primary immune cells.

  • Firm grasp of the challenges of scaling up a cell therapy production process from research to manufacturing.

  • Sound conceptual understanding of and ability to interpret results from cellular and molecular analytical techniques, like multi-parameter flow cytometry, Incucyte-based assays, cytotoxicity assays, ddPCR, NGS, qPCR, etc.

  • Ability to multitask, independently organize time, and plan specifics of work.

  • Excellent communication and facilitation skills demonstrated in a team environment.

  • Willingness to think outside the box, be creative and ability to work in a very fast paced, ever changing environment.

The starting compensation for this job is a range from $102,000 to $129,000 plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Years holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement,fertility/infertilitybenefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

#LI-Onsite

If you come across a role that intrigues you but doesnt perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as Transforming patients lives through science , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

Company

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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Company info
Website
Telephone
+1-800-332-2056
Location
430 E. 29th St
14th Floor
New York
New York
10016
United States

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