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Research Associate II, Cell Biology - Neurology

Employer
BioMarin Pharmaceutical Inc.
Location
San Rafael, California
Start date
Nov 27, 2023

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Discipline
Regulatory, Science/R&D, Biology, Cell Biology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

Who We Are

From research and discovery to post-market clinical development, our WWRD engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with genetic diseases.

The Neuroscience Research group at BioMarin is seeking a Research Associate II with experience in utilizing iPSC and other relevant culture systems to investigate neurological disease mechanisms and advance novel treatments.

The Research Associate II in Neuroscience Cell Biology will join and assist a team of neuroscience-focused cell biologists in advancing early-stage therapeutic programs targeting the underlying genetic causes of neurological diseases.  Employing cutting-edge in vitro approaches, he/she will assist in the development of novel, advanced cellular models of human disease in order to screen therapeutic compounds, and to identify, optimize and progress therapeutic leads.  In doing so, the Research Associate II will establish themselves as a technical specialist in iPSC method development (including co-culture and 3D cellular modeling) and work diligently across functions to contribute to diverse areas including functional assay development, phenotypic characterization, drug mechanism of action and biomarker identification. 

The successful candidate will ideally have a strong background in neuroscience, cell and molecular biology, iPSC culture, microscopy and pharmacology/drug discovery.  He/she will have excellent interpersonal skills and a strong track record of utilizing collaboration to advance therapeutic programs.  The candidate will interact with the Head of Neuroscience, Director of Cell Biology in Neuroscience, and Research and Early Development Team to provide critical updates on the Neuroscience portfolio and specific programs.

 

RESPONSIBILITIES:

1.               Establish in vitro screening platforms and disease models for neurological indications

o  Assist in the development and validation of stable iPSC cell models of excitatory and inhibitory neurons, motor neurons and other disease-relevant subtypes

o  Employ cellular models to identify and validate new targets

o  Evaluate complex new methods and culture systems, including co-culture and 3D models of multiple CNS cell types, identify new areas requiring method improvement and adapt existing methods or develop new ones with direct input and supervision from a manager

 

2.               Identify and optimize lead compounds for early-stage neuroscience programs

o  Contribute to the identification and selection of lead compounds utilizing iPSC cellular models

o  Execute experiments to understand molecular and cellular mechanisms underlying therapeutic efficacy, variability, and durability

o  Utilize in vitro toxicity assays to predict safety and off-target effects of development candidates

 

3.               Cross-team collaboration and engagement, data analysis and organizational skills

o  Committed to overcome challenges and ability to troubleshoot

o  Ability to solve complex scientific and technical issues independently

o  Contribute to scientific publications and regulatory submissions as required

o  Perform quantitative analysis within and across multiple experiments, interpret results and provide feedback on implications for program progression

o  Collaborate with various BioMarin functions, CROs, university or analytical laboratories, business partners, as necessary to ensure appropriate/timely progression of projects

o  Excellent written and verbal communication skills

o  Contribute to productive cross-functional collaborations both within and external to BioMarin

o  Thoroughly record and document experimental methodology and results

Education & Experience Level:

·         Bachelor’s degree in neuroscience, molecular biology, biochemistry or related with 4+ years of relevant experience OR Master's degree with 2+ years of relevant experience

 

 We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.

Company

BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.

Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.

Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.

Company info
Website
Location
California
United States

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