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Scientist, Gene Editing, Off-Target

Life Edit Therapeutics
Durham, NC
Start date
Nov 24, 2023

View more

Clinical, Science/R&D, Biotechnology, Genetics
Required Education
Position Type
Full time
Bio NC

Job Details

The Role:

We are looking for an enthusiastic, competent, and self-motivated Scientist with a strong background in molecular biology and genome editing to join our Gene Editing team to help expand our off-target platform.


Here’s What You’ll Do:

  • Design, execute, and troubleshoot molecular biology and cell biology experiments to profile the off-target characteristics of lead Life Edit genome editing systems
  • Develop off-target assays across multiple cell types and editing modalities
  • Analyze experimental data and present scientific results at team research meetings and in formal reports
  • Contribute to publications and patent applications
  • Follow advancements in the field of gene editing published in the literature and presented at conferences
  • Collaborate closely with the Computational Biology, Technology Development, and Preclinical research groups
  • Assist in day-to-day laboratory operations


  • Ph.D. in Biology, Biochemistry, Cell Biology, or a related field  
  • Extensive expertise with common molecular biology techniques including PCR, library generation, and DNA modification
  • Expertise in biochemical isolation and analysis techniques for DNA, RNA, and protein
  • Demonstrated hands on experience in mammalian tissue culture including primary cell culture with experience in multiple delivery methods including nucleofection, lipofection, and lipid nano particles is strongly preferred
  • Relevant technical skills for data analysis, DNA and protein sequence analysis, ELN documentation, and presenting results
  • Demonstrated ability for cross-functional collaboration in a team-oriented environment
  • Exceptional oral and written communication skills
  • Experience with genome editing technology including off-target analysis techniques is strongly preferred
  • Experience with and conceptual understanding of NGS techniques
  • Industry experience preferred



We’re committed to finding the best ways to support our teams so they can do their best work. We take care of our employees, right from the start.

Health & Wellness

  • Medical, vision, and dental insurance covered at 90%
  • Low deductible, no co-insurance and no copays for mental health visits (for in-network care)
  • Annual fitness reimbursement
  • Employer paid for access to wellness apps and programs like Task Human


  • Competitive compensation
  • 401(k) retirement plans with a 4% employer match and no vesting period
  • Employer-paid life insurance and short- and long-term disability insurance
  • Employer-sponsored flexible spending accounts (FSA) and dependent care account (DCA)
  • Access to a 1-on-1 financial advisor
  • Commuter reimbursement benefit
  • Monthly cell phone stipend

Time Off & Flexibility

  • Unlimited paid time off, including vacation, sick leave, family leave, personal days, and bereavement
  • 18 paid company holidays, plus an end-of-year holiday shut down
  • 12 weeks of parental leave
  • Federal Family and Medical Leave Act (FMLA) and Massachusetts Paid Family and Medical Leave (PFML), administered by Unum

Development Journey

  • Insights Discovery training for every employee to make the most of workplace relationships
  • Ongoing professional development, including manager training
  • Access to LinkedIn Learning, a self-guided online education platform


Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics.Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.


Life Edit Therapeutics, an ElevateBio company, is a next-generation genome editing company that has built a highly innovative platform with one of the world’s largest and most diverse collections of novel RNA-guided nucleases (RGNs) and base editors. The platform allows Life Edit to target any genomic sequence and develop novel human therapeutics for the most challenging genetic diseases by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies. In addition to developing its own pipeline of cell and gene therapies, Life Edit Therapeutics will continue to strengthen its platform of genome-editing enzymes, provide gene-editing expertise to strategic partners, and form other third-party partnerships to discover and develop new therapies.



Company info
507 Airport Blvd. Suite 101

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