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Research Associate III

Employer
Frederick National Laboratory for Cancer Research
Location
Frederick, MD
Start date
Nov 21, 2023

View more

Discipline
Regulatory, Research/Documentation, Science/R&D, Research
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
BioCapital

Job Details

Research Associate III

Job ID: req3764
Employee Type: exempt full-time
Division: Vaccine, Immunity and Cancer
Facility: Frederick: Ft Detrick
Location: PO Box B, Frederick, MD 21702 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION         

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases. 

The Vaccine, Immunity, and Cancer Directorate (VICD) at the Frederick National Laboratory has a primary mission to provide scientific leadership and laboratory infrastructure to study immune responses to Human Papillomavirus (HPV) vaccines and other cancer preventive strategies in the context of clinical and pre-clinical studies. More recently, VICD is also leading initiatives on SARS-CoV-2 infection and vaccines. 

The mission of the Cancer ImmunoPrevention Lab (CIPL) within the VICD is to serve as a reference and technical support laboratory, performing work necessary to advance successful immunoprevention concepts such as cancer vaccines in preclinical development towards the ultimate goal of IND and clinical evaluation.

KEY ROLES/RESPONSIBILITIES

Responsibilities include, but are not limited to, the following:

  • Perform tissue culture and immunological/virological techniques, including aseptic techniques, cell line maintenance, production of plasmids and virus-like particles. 
  • Produce RNA constructs through in vitro transcription, then test antigen expression through mass spectrometry and Western blot.
  • Optimize and validate procedures and methodologies for assessment of immune responses to infection and vaccines.
  • Plan and conduct experiments in mouse vaccine models.
  • Perform immunological assays that include ELISA, ELISPOT, Luminex assays, flow cytometry, cell-based neutralization assays, immunohistochemistry.
  • Design and implement protocols, as well as troubleshoot assays and experiments independently.
  • Evaluate, analyze and compile data, maintain databases.
  • Responsible for routine QC/QA procedures, ordering supplies, and maintaining equipment and inventories.
  • Prepare reports, present data and participate in report and proposal preparation.
  • Remain current on literature and relevant laboratory techniques.
  • May supervise lab personnel.
  • Perform other duties as assigned. 
BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

  • Possession of a Bachelor's degree in immunology, vaccinology, or molecular biology or related field from an accredited    college/university according to the Council for Higher Education Accreditation (CHEA).  (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
  • In addition to the education requirement, a minimum of eight (8) years related biomedical laboratory experience.
  • Detailed knowledge of vaccines, immunology, and virology.
  • Expertise in tissue culture and immunological/virological techniques, including aseptic techniques, cell line maintenance,  production of plasmids and virus-like particles, Western blot, ELISA, ELISPOT, Luminex assays, flow cytometry, virus          neutralization assays and PCR.
  • Ability to obtain and maintain a security clearance. 
PREFERRED QUALIFICATIONS

Candidates with these desired skills will be given preferential consideration:

  • MS or Ph.D. in immunology, vaccinology, virology or molecular biology.
  • Experience managing personnel and lab operation.
  • Experience in immune assays (ELISA, ELISPOT, flow cytometry) development and validation.
  • Experience handling large data sets, statistics, software tools (Word, Excel, PowerPoint)
  • Expertise in molecular biology techniques including plasmid DNA cloning, RNA synthesis, sequencing, microarray, single cell genomics, RNASeq.
  • Experience using robotics.
JOB HAZARDS
  • This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations.

Commitment to Diversity
All qualified applicants will receive consideration for employment without regard to sex, race, ethnicity, age, national origin, citizenship, religion, physical or mental disability, medical condition, genetic information, pregnancy, family structure, marital status, ancestry, domestic partner status, sexual orientation, gender identity or expression, veteran or military status, or any other basis prohibited by law. Leidos will also consider for employment qualified applicants with criminal histories consistent with relevant laws.

#readytowork

Company

A rewarding career with global impact

Whether you’re an expert in your field or just starting out, we have a career opportunity for you. We’re always looking for people to join us in fulfilling the mission of the Frederick National Laboratory: discovery, innovation, and success in the biomedical sciences.

Our team of 2,400+ scientists, technicians, administrators, and support staff work at the forefront of basic, translational, and preclinical science, with a focus on cancer, AIDS, and other infectious diseases.

We collaborate with colleagues across the National Cancer Institute, National Institutes of Allergy and Infectious Diseases, and others throughout the National Institutes of Health. We also engage with extramural investigators in academia, government and industry.

Your path to joining our team begins with the desire to work for the only national laboratory dedicated to biomedical research. Our employees share a common desire to help make a difference in cancer research and public health concerns. As you search for a career that fits your education, skills, and abilities, explore the core values that guide us and emphasize work-life balance.

Discover why joining the Frederick National Laboratory team could be the most important career step you take

 

 

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Company info
Website
Telephone
301-846-1000
Location
8560 Progress Drive
Frederick
MD
21701
US

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