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Scientist, RNA Assay Development

Employer
Life Edit Therapeutics
Location
Durham, NC
Start date
Nov 18, 2023

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Discipline
Science/R&D, Biotechnology
Required Education
Doctorate/PHD/MD
Position Type
Full time
Hotbed
Bio NC

Job Details

The Role:

We are looking for a motivated scientist at the interface of RNA and nanoparticle biology. In this position, you will work to improve our non-viral delivery therapeutics by characterizing Life Edit’s novel RNA-guided nucleases (RGNs) and guide RNAs as they move from research to preclinical evaluation and eventual clinical advancement.  You will work on the RNA team to develop assays to assess the quality and potency of RNA. Applicants will be expected to execute planned experiments in a timely manner and effectively communicate results and/or roadblocks. This is a great opportunity for a scientist to develop highly relevant industry experience while developing transformative RNA-based therapeutics. The candidate should possess strong organizational and communication skills and the desire to be part of a highly collaborative and cross-functional team.

Here’s What You’ll Do:

  • Develop assays to test the potency and quality of RNA-based therapeutic products. These assays will include purity assessment, RNA integrity, LNP encapsulation efficiency and stability using relevant assays (HPLC, LC-MS, Ribogreen, CE, PAGE, UV-VIS, etc.).
  • Work closely with RNA team, formulation team, and preclinical team members to improve RNA based gene editing therapeutics.
  • Write study specific procedures for analytical methods, protocols, and reports and provide training on processes and equipment.
  • Document experimental results in ELN.
  • Communicate experimental results in group meetings.

 

Requirements:

  • Biology, biochemistry, molecular biology, or cell biology background. (Ph.D in related field is a plus)
  • Knowledge and experience in bioanalytical skills such as analytical characterization assays and RNA isolation/quantitation assays (CE, PAGE, Western blot, AGE, UV-Vis, HPLC).
  • 1-2 years of relevant laboratory experience. Familiarity with basic laboratory skills such as running gels, nucleic acid purification, etc. (RNA-biology related lab experience is a plus)
  • Good organization & communication skills
  • Experience working with CRISPR or other gene editing systems is a plus

Why join Life Edit and the ElevateBio ecosystem?

Life Edit Therapeutics is an integrated subsidiary of ElevateBio, a technology-driven cell and gene therapy company that is accelerating access to the cutting-edge technologies and expertise that can change the future of medicine. Our integrated model combines multiple R&D technology platforms – including Life Edit gene editing – and cGMP manufacturing to power the discovery and development of advanced therapeutics.Our ecosystem is designed to enhance speed, delivery, and probability of success to change patient lives.

Life Edit is an integral part of ElevateBio’s ecosystem of platform technologies and is pioneering focused next-generation gene editing technologies and therapeutics. Located in Durham, NC, members of Life Edit work closely with the ElevateBio Research and Development and BaseCamp manufacturing teams in Waltham, MA. Life Edit is advancing therapeutic programs in collaboration with industry partners while building its own internal pipeline of gene editing therapies. We are looking for a unique individual who can continue to lead the cultural development of Life Edit and build on its momentum as an integral part of the ElevateBio ecosystem.

Our Mission:
To power the creation of life-transforming cell and gene therapies, at a speed the world deserves.

Our Vision:
We seek to be the world’s most indispensable cell and gene therapy technology company, redefining how companies operate, how products are created and how disease is treated.

ElevateBio is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. ElevateBio will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Company

Life Edit Therapeutics, an ElevateBio company, is a next-generation genome editing company that has built a highly innovative platform with one of the world’s largest and most diverse collections of novel RNA-guided nucleases (RGNs) and base editors. The platform allows Life Edit to target any genomic sequence and develop novel human therapeutics for the most challenging genetic diseases by enabling ex vivo engineering for cell therapies and regenerative medicines and in vivo delivery of gene therapies. In addition to developing its own pipeline of cell and gene therapies, Life Edit Therapeutics will continue to strengthen its platform of genome-editing enzymes, provide gene-editing expertise to strategic partners, and form other third-party partnerships to discover and develop new therapies.

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Company info
Website
Location
507 Airport Blvd. Suite 101
Morrisville
NC
27560
US

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