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Principal Scientist/Associate Director, Mammalian Cell Culture Development

Ambrx, Inc.
La Jolla, CA
$145,000 to $175,000
Start date
Nov 11, 2023

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Science/R&D, Biotechnology
Required Education
Masters Degree/MBA
Position Type
Full time
Biotech Beach

Job Details

(Job: 2023-BR-07)

About Ambrx:

Ambrx is a clinical-stage biopharmaceutical company enabling a new field of protein medicinal chemistry, using a technology that directs the incorporation of amino acids beyond nature’s conserved set into biosynthetic proteins to produce high value biological products such as antibody-drug conjugates. Ambrx is seeking a highly motivated scientific leader to be a key member of a fast-paced and dynamic organization.

Job Description:


This position will focus on upstream process development and lead the efforts for developing and optimizing the cell culture process including medium development, feeding strategies, process parameter optimization, process characterization and scale-up for large scale production to support R&D, pre-clinical, and clinical activities. This individual will design and carry out experiments and provide technical leadership and serve as the subject matter expert on project teams and work closely with other groups to provide support for the Company’s projects. The candidate will monitor, explore and evaluate next generation technologies to speed up process development. This individual will also be responsible for technology transfer to third parties including partners and CMO.. The role will involve authoring of development reports and CMC sections for regulatory submissions including INDs and BLAs.


  • Ph.D with 8+ yrs industry experience or MS with 12+ yrs industry experience in Biochemical Engineering, Chemical Engineering, Biochemistry or related field
  • Hands-on experience with CHO and other mammalian cell for mAb or recombinant protein production is a must
  • Hands-on experience using spin tubes, shake flasks, stirred tank bioreactors, automated microbioreactor systems and ATF equipemnt is required
  • Previous experience in cell culture scale-up, tech transfer including drafting development reports, production batch records, protocols and Knowledge of scale-up and scale-down models is highly desired.
  • Knowledge of statistical design of experiments in process development and optimization
  • Previous experience in cell culture media development and cell culture platform development is plus
  • The ability to succeed in a multidisciplinary, fast changing and diverse team environment
  • Working knowledge of GMP and experience with US IND/BLA filings are highly desirable


Pay Scale:

The annualized pay scale for this exempt position is: $145,000 to $175,000, commensurate with experience.  We believe this to be possible compensation for this role at the time of this posting, and we may modify this pay scale in the future.


Ambrx®, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics using an expanded genetic code. Unlike conventional conjugation techniques that create a mixture of suboptimal molecules, Ambrx technology combines site specific conjugation with proprietary linkers, payloads and pharmacokinetic extenders to create a single molecular species that is optimized for safety, efficacy and biophysical properties. We call this process Protein Medicinal Chemistry™.

Protein Medicinal Chemistry™ can optimize any protein or antibody to create potentially best-in-class therapeutics such as long-acting proteins, bi-specifics and antibody drug conjugates. The Ambrx advantage allows us to safely and effectively target cytotoxic agents or recruit effector function to tumor cells (oncology) or modulate biological pathways implicated in disease areas such as autoimmune, metabolic and cardiovascular.

At Ambrx, we are dedicated to assembling and developing an exceptional team and a novel technology to create the next generation of protein-based medicines.

Company info
10975 North Torrey Pines Road
La Jolla
United States

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