This job has expired

You will need to login before you can apply for a job.

Senior Scientist – Molecular Design

Employer
Terray Therapeutics
Location
Flexible (Remote or Monrovia, CA)
Start date
Nov 10, 2023

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time

Job Details

Company Overview

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data mapping interactions between small molecules and causes of disease that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Position Summary

Terray is currently seeking a motivated, creative, and experienced senior scientist to join our molecular design group. As an integral member of the Computational and Data Sciences (CDS) team, the candidate will contribute to hit-to-lead and lead optimization efforts across multiple programs, leveraging our vast chemical datasets and proprietary wet-lab + computational platforms to power state-of-the-art small molecule design. In this interdisciplinary role, the candidate will work closely with the chemistry and biology functions at Terray, as well as the machine learning and data science teams within CDS. 

The core responsibilities of this position are:

  • Design small molecules with in-house, high-throughput computational tools using both structural models and ligand-based data from our proprietary screening platform
  • Develop workflows to triage and further investigate hits from our screens
  • Design multi-million member combinatorial libraries to drive small molecule programs in hit-to-lead and lead optimization
  • Develop and evaluate models to predict affinity and other properties of interest in collaboration with the machine learning team, and apply them prospectively for virtual screening and design (including generative design)
  • Communicate molecular design strategy and outcomes to teams across the company
Experience and Qualifications

Part of Terray’s success is nurtured by a hands-on work environment where everyone is accountable, vested in a vision of excellence, and actively taking part in the success of the business. Terray supports a positive work environment where employees can feel engaged, recognized and empowered to be creative.

Required Qualifications
  • BS/MS/Ph.D in computational, organic, or medicinal chemistry, or a related field
  • Experience applying ligand-based and structure-based methods to designing small molecules for multiple drug discovery projects
  • Experience working with medicinal chemists to optimize ADME and safety issues
  • Experience triaging large data sets from virtual screens, DEL screens, and/or HTS
  • Experience with RDKit, one molecular simulation suite (Schrodinger, MOE, etc.), and one docking program (AutoDock Vina, rDock, etc.)
  • Proficient in Python and the PyData stack (numpy, pandas, scipy, scikit-learn, etc.) 
Compensation Details

$132,000 - $240,000 (annually) depending on seniority; participation in the Company's option plan; 3% 401K contribution; full benefits

Company

Terray is a biotechnology company with the technology, data, and mindset to radically change the way we discover and develop small molecule therapeutics. We explore molecules and targets broadly and deeply with a sophisticated integration of ultra-high throughput experimentation, generative AI, biology, medicinal chemistry, automation, and nanotechnology. Everything the company does is grounded in an iterative approach, producing massive amounts of precise, purpose-built data that gets increasingly valuable with each cycle of design and experimentation. The company’s platform uniquely blends experimentation and computation to improve the cost, speed, and success rate of small molecule drug discovery and development.

Company info
Website
Location
750 Royal Oaks, Suite 100
Monrovia
CA
91016
United States

Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert