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Scientist 2, Analytical Sciences - Molecular Biology

BioMarin Pharmaceutical Inc.
Novato, California
Start date
Sep 29, 2023

Job Details




BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind. 


BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. The Analytical Chemistry department, a part of Process Sciences within Tech Ops, supports all assay needs in Tech Ops. Our scientists and associates are experts in analytics of small molecules, peptides, proteins/enzymes, and gene therapy agents. We develop assays to follow the quality attributes of our products, support IND and BLA applications, we assess the capability of our processes by analyzing in-process samples all the way from bioreactors through purification steps to the drug substance and develop release assays for transfer to Quality. We are also instrumental in time-critical analysis support to Manufacturing as needed. Come join our team and make a meaningful impact on patients’ lives.





The Analytical Chemistry department at BioMarin Pharmaceutical Inc. is seeking a Scientist 2 to join a method development team focused on supporting gene therapy clinical programs. The successful candidate will be a self-motivated and critical thinker who has proven ability to work in a multi-disciplinary and fast-paced environment, and solid communication skills.


The candidate will be responsible for developing new AAV analytical methods with a focus on molecular biology and PCR-based techniques.  They will develop and qualify methods, manage sample testing, and compile and communicate results. The selected candidate should possess excellent organizational, analytical and communication skills and be a self-starter willing to work efficiently and collaboratively in a dynamic environment. 


An ideal candidate will have significant experience in molecular biology and PCR-based assays, analytical method development, and data handling. A good scientific understanding of protein chemistry and biochemistry is essential. Hands-on experience in AAV analytics and a prior knowledge of ICH and regulatory submission is a plus.





  • Execute relevant experiments to support development of analytical assays and sample testing and for AAV gene therapies in the clinical pipeline
  • Develop analytical methods using molecular biology techniques, PCR, dPCR, multiplex dPCR, electrophoresis, and HPLC
  • Execute relevant AAV nucleic acid characterization experiments to support manufacturing process development
  • Provide concise and quantitative analysis of data and interpretation of experimental results
  • Ensure laboratory equipment has current calibration and preventative maintenance documentation
  • Report progress to the manager on a regular basis on each program
  • Write up methods, development reports, qualification reports, results & share with collaborators and supervisor; present data proactively and regularly in group meetings; communicate plans and results to collaborators and manager iteratively
  • Catalogue data/reports electronically in an accessible manner for inspections.





Required Skills:

  • Good understanding of nucleic acid and protein chemistry, structure, and function
  • Knowledge in standard nucleic acid molecular biology analysis methods (e.g. Primer Design, PCR, ddPCR, electrophoresis, CE, HPLC)
  • Collaborative skills to work in a cross-functional environment
  • Excellent communication, collaboration and writing skills
  • Proven data analysis, interpretation and scientific communication skills
  • Proven flexibility and execution skills to deliver in a fast-paced, multi-tasking environment


Desired Skills:

  • Experience in AAV analytics
  • Knowledge of biopharmaceutical development
  • Experience with method qualification and transfer
  • Knowledge of ICH and regulatory submissions




Ph.D. degree in biological sciences, biochemistry, or chemistry and at least 2 years of relevant post graduate experience


For this role, a minimum of 2 days per week onsite is required.  There is a laboratory component to the role, however, and onsite presence for lab work or lab oversight will be driven by the project needs.  Some weeks will require just the minimum 2 days onsite, some weeks may require 5 days onsite. 


Thermocyclers, digital droplet generators, HPLC, electrophoresis systems, CE, SDS-PAGE, MALS




Will report to a PhD Director in Analytical Chemistry



May supervise, mentor, and manage Research Associates


BioMarin is a global biotechnology company dedicated to transforming lives through genetic discovery. In 1997, the company was founded to make a big difference in small patient populations, focusing on giving much-needed attention to the underserved communities of those with rare diseases. BioMarin sought to help patients whose voices could not always be heard and treat conditions that were not always in mainstream medical conversations. Throughout its history, BioMarin has worked tirelessly to make a difference by pursuing bold science. The company’s first approved therapy was inspired by a father who refused to accept there was no therapy for his son’s rare diagnosis. That relentless pursuit to change the course of his son’s future through the power of science is at the core of who BioMarin is today.

Through the company’s expertise in genetics and molecular biology, BioMarin has developed eight first or best-in-class targeted therapies that address the root cause of the conditions it seeks to treat, helping to better the lives of those struggling with rare genetic disease. The company’s purposeful and scientifically precise team of physicians and scientists has honed each treatment modality to seek transformative therapies.

Now, BioMarin seeks to make an even greater impact by applying the same science-driven, patient-forward approach that propelled the last 25 plus years of drug development to larger genetic disorders, as well as genetic subsets of more common conditions. Each drug candidate pursued is guided by a fundamental understanding of the genetics and underlying biology of the condition it will address. The company believes that applying its knowledge to make a transformative impact is not just a calling, but an obligation to those who will benefit most. The more innovative solutions developed, the more lives BioMarin can impact.

Company info
United States

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