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Scientist I, DNA Encoded Library Technology – Discovery Chemistry

Nurix Therapeutics
San Francisco, CA
Start date
Sep 26, 2023

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Science/R&D, Biotechnology, Chemistry
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay

Job Details


We are seeking a talented and highly motivated chemist with a strong background in DNA-encoded library (DEL) synthesis to join our Discovery Chemistry team. In this laboratory-based position, you will be part of a highly versatile team that is focused on advancing projects though Nurix’s on-DNA to off-DNA lead discovery platform. The successful candidate will have the opportunity to directly contribute to the following key platform operations:

  • Plan and execute on-DNA DEL hit resynthesis campaigns.
  • Design and validate novel DEL library builds.
  • Develop and bring in new DNA-compatible chemical transformations that can widen the DEL chemical space.
  • Construct DEL libraries to support the in-house library production efforts.
  • Work with external partners to support our DEL synthesis and hit follow up strategies.
  • Engage in cross-functional team discussions that support DEL screening, data analysis, machine learning and hit-optimization.
  • Influence high-throughput platform automation and technology development efforts.
  • Contribute to scientific strategies and group goals focused on discovery stage hit-to-lead identification and optimization.
  • Prepare reports and present data at internal group meetings.

Education and Experience

  • Ph.D. in Medicinal Chemistry with up to 4 years relevant experience OR MS with 6+ years relevant experience, OR BS or equivalent with 10+ years relevant experience.
  • Strong background in synthetic organic chemistry.
  • Hands-on laboratory experience in carrying out on-DNA synthesis and methodology development.
  • Familiar with the overall DNA-Encoded Library Technology workflow operations.
  • Experience analyzing and purifying DNA-conjugates using common analytical tools (LCMS/HPLC).
  • Experience working in the drug discovery field – drug design, synthesis, and SAR based hit-to-lead optimization.
  • Established track record of conference presentations and peer-reviewed publications in the areas of Organic Chemistry and DNA-Encoded Library Chemistry

Added Quantifications

  • Postdoctoral or industrial work experience in the DEL field.
  • Experience working in the PROTAC-based drug discovery programs.
  • Experience working with high-throughput analytical and purification systems relevant to DEL-applications.
  • Experience working with molecular biology tools (PCR, qPCR, Western Blot)

Fit with Nurix Culture and Values

  • Strong team orientation and highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Nurix Therapeutics, Inc. is committed to protecting and respecting your privacy and personal information, including information collected by Nurix when you apply for a job with Nurix or in the course of your employment with Nurix.  By applying for a position at Nurix, you agree to our collection and use of personal information as described in our Privacy Policy ( 


Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.

Company info
1700 Owens Street
Suite 205
San Francisco

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