Postdoctoral Fellow, Connective Tissue Diseases

Join us in the Connective Tissue Diseases Therapeutic Focus Area for an exciting postdoctoral position! We're searching for a highly qualified, innovative, and collaborative researcher with a curiosity for "outside of the box" thinking.

Your mission will be to unravel the physiological roles of the type 1 Bone Morphogenetic Protein receptor ACVR1 and explore its signaling mechanisms.

ACVR1 sets itself apart by forming two distinct complexes: a potent signaling complex with BMPs and a non-signaling complex with Activins. Our preliminary findings indicate that these complexes play distinct physiological roles. To delve deeper, we've developed advanced tools to dissect them both in vitro and in vivo. By gaining a comprehensive understanding of each complex's functions, we aim to redefine therapeutic strategies for diseases involving ACVR1 and related receptors.

If you're ready to make an impact and embark on an outstanding scientific journey, apply now! Join our team of driven researchers as we unlock the secrets of connective tissue diseases and pave the way for innovative treatments.

As a Postdoc, a typical day might include:

• Independently crafting, planning, and performing/supervising in vitro studies, developing bioassays, and analyzing signaling pathways.

• Applying basic molecular biology techniques and demonstrating expertise in cell culture, including immortalized and embryonic stem cell lines.

• Performing animal experimentation, dissecting tissues, and collecting samples for analysis.

• Designing and leading all aspects of advanced flow cytometry (FACS) panels, as well as using imaging methodologies such as confocal microscopy. Familiarity with techniques for visualizing receptor location and trafficking are highly desirable.

• Collaborating with cross-functional teams, presenting compiled results, documenting procedures, and contributing to publications and conference presentations.

• Continuously following the current relevant literature, attending scientific meetings, and maintaining expertise in the field of BMP/TGF signaling and corresponding biology, as well as new areas as needed.

• Participate in post-doctoral program activities (e.g., weekly meetings and annual research conference)

• Publishing your groundbreaking research and presenting it at conferences.

This role may be for you if you:

• Possess a strong desire to contribute to groundbreaking discoveries that challenge existing notions of BMPs and TGFs signaling.

• Demonstrate self-motivation, creativity, and a successful background in signal transduction, preferably with experience in laboratory mouse experimentation. We value relevant publications, a passion for basic research, and an interest in translational opportunities.

• Showcase outstanding scientific skills, including critical and analytical thinking.

• Exhibit strong communication and presentation abilities.

• Possess excellent organizational and time management skills, effectively handling multiple tasks and prioritizing them.

• Display creativity, independence, and the ability to thrive in cross-functional team projects.

To be considered for this role, you must have a Ph.D. in biochemistry, cell biology, developmental biology, or molecular biology. We need someone with hands-on experience in techniques such as flow cytometry, microscopy, cell culture, and mouse experimentation. Expertise in imaging methodologies is highly desired. You will get the opportunity to lead a research project in a fast-paced and results-driven environment.

Please note, the specific starting salary for this role is $86,000.

#postdoc #postdoctoral #earlycareers

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$69,500.00 - $113,500.00