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Principal Scientist, Analytical Research

Moderna, Inc.
Cambridge, MA
Start date
Sep 13, 2023

Job Details

The Role

We are seeking an experienced and highly motivated Principal Scientist to lead our Analytical Research team. The ideal candidate will have extensive experience in the biopharmaceutical industry, with experience in both large and small molecule analytical development. Primary responsibilities include building, leading, and providing technical and strategic oversight to a team of digital-first analytical scientists focusing on method development, characterization, and impurity identification for large molecules, small molecules, and mRNA lipid nanoparticle formulations in Modernas Discovery organization. This role manages overall analytical deliverables and timelines to meet discovery program needs. Further responsibilities include working with Technical Development to transfer phase appropriate analytical strategies. This is a laboratory-based technical leadership position.

This role will be located at the Moderna Science Campus in Cambridge, MA. The individual will be a leading contributor to mRNA-LNP drug substance and drug product analysis from early Discovery to candidate nomination into clinical development.

Heres What Youll Do

  • Lead a matrix team of analytical scientists working on method development for identification, structure elucidation, and characterization of LNP-based pharmaceuticals and their components (large and small molecules) using biochemical techniques (gel electrophoresis, nucleic acid/protein purification, PCR) and analytical techniques (LC-UV/CAD, high-resolution LC-MS/MS, and GC-MS/FID)

  • Develop and implement method qualification/validation strategies, and overall analytical control strategies for small molecule/lipids across mRNA-LNP modalities in a discovery phase appropriate manner

  • Design and implement high-throughput next generation analytics, and create the digital data systems for analytical data flow

  • Drive technical discussions, define action items and deliverables, author and review analytical documentation, and provide technical oversight and leadership across the portfolio of programs in Discovery

  • Serve as a strategic and technical partner to the Research Organization, Analytical Development, and Analytical Technical Operations, and work with the Discovery, Non-clinical Sciences, and Technical Development teams to ensure meeting analytical deliverables, timelines and alignment with program development activities and milestones

Heres What Youll Need (Minimum Qualifications)

  • MS with 10 15 years, or Ph.D. in Chemistry, Biochemistry, Molecular Biology, Organic Chemistry, or closely related field with over 7 years of relevant industry experience in analytical chemistry

  • Expertise in biochemical techniques on various instrumentation platforms (e.g., gel electrophoresis, nucleic acid/protein purification, cell culture and cloning, enzymatic reactions such as PCR, reverse an T7 transcriptions, NA digestions and ligations)

  • Knowledge and extensive hands-on experience in large and small molecule analytics, including method development (mass spectroscopy, separation techniques (UPLC, HPLC, CE), and NMR spectroscopy) for the identification, characterization and structure elucidation of RNA, proteins, lipids, and nanoparticles, with sound knowledge and proven experience in developing and implementing validated high-throughput analytical methods

Heres What Youll Bring to the Table (Preferred Qualifications)

  • Strong ability to drive team towards best practices demonstrating leadership qualities in a fast-paced environment and demonstrate managerial abilities and strong technical leadership in both direct reporting relationships and in a matrix and cross-functional environment to execute on strategy

  • Experience in data visualization, analysis and statistical evaluation of data (JMP, Spotfire, Dry Labs) and programming in common computing languages (C, Python)

  • Strong interpersonal skills with an eagerness to work with and support colleagues in other departments

  • Ability to navigate through ambiguity and rapid growth and adapt to change

  • Knowledge of current FDA and ICH guidelines

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary year-end shutdown
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

About Moderna

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, theinfrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our peopleare the driving force behind our scientific progress and our culture.Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit to learn more about our current opportunities.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. Were focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at (EEO/AAP Employer)




Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.


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Company info
200 Technology Square
Cambridge, MA
United States

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