Associate Scientist, in vivo - Neuroscience

We are seeking a highly motivated Associate Scientist to join the Neuroscience Therapeutic Focus Area (TFA) at Regeneron Pharmaceuticals. Our team is dedicated to collaborative research to develop new delivery technologies and therapeutic strategies for nervous system diseases. This includes Parkinsons Disease, Multiple System Atrophy, Dementia with Lewy Body, Alzheimers, Fronto-Temporal Dementia, Motor Neuron Disorders, Autism Spectrum Disorder, Schizophrenia, Depression, and Pain.

In this role, you will lead and support projects to design, develop and functionally validate gene therapy and gene editing tools, novel viral vectors, and nucleic acid therapeutics for treating neurodegenerative disorders. You will support technology development for antibody-based strategies to improve targeted drug delivery across the blood-brain barrier (BBB) to the CNS and into specific tissues and cell types of interest.

As an Associate Scientist in the Neuroscience team, a typical day might include the following:

• Designing and conducting experiments to evaluate the biodistribution and validate novel targeted drugs (siRNAs, ASOs, shRNAs, CRISPR systems, vectorized antibodies or peptides) and viral vectors in in vivo models.

• Planning, initiating, and completing in vivo experiments: Mouse handling and monitoring, behavioral assays, anesthesia, dosing (IV, IP, SQ, RO), surgeries (including stereotaxic surgeries), dissections and sample collections (brain, peripheral tissues and biofluids).

• Conducting sample processing and analysis with molecular biology, biochemical and immuno-based assays: RT-qPCR, RNA sequencing, ELISAs,WB, CE-western.

• Performing histology: Tissue processing, fixation, cryopreservation, tissue sectioning (vibratome, cryostat, microtome), handling of histological slides and basic histological staining methods, IF, IHC, RNAscope ISH methods, IHC/ISH multiplex assays.

• Conducting light and fluorescent imaging of histological sections with conventional microscopes, confocal microscopes and high-throughput slide scanners.

• Performing data collection and analysis (cell counting, unbiased stereology, quantifications in Halo, Image J, Prism)

• Troubleshooting, optimizing and developing new assays under minimal supervision.

• Keeping up-to-date and well-organized records of experimental protocols and results.

• Surveying current and relevant literature to improve scientific and technical knowledge, introducing novel concepts to optimize and develop new assays.

• Communicating and reporting experimental findings at group and department meetings.

This role might be for you if you:

• Enjoy working in a highly collaborative and fast-paced environment.

• Possess strong organizational and time management skills to advance projects in parallel optimally.

• Exhibit excellent communication and presentation skills.

• Demonstrate scientific rigor and pay attention to details.

To be considered for this opportunity, you must have a Masters degree in biology, neuroscience or a related field with 2 - 3+years of lab experience. Experience in Neuroscience, Neuroanatomy, and in vivo models of neurodegenerative disorders are highly desirable.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$66,400.00 - $103,800.00