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Executive Director, PSC Process Development

Sana Biotechnology
Cambridge, MA
Start date
Sep 7, 2023

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Job Details

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge status quo, and who lead with the desire to work on novel ideas. As a Head of Pluripotent Stem Cell (PSC) Process Development, you will report to Head of Cell Therapy Process Development and provide the strategic leadership to establish and drive the execution of the organization. You will drive strategies for developing scalable manufacturing processes to support Sana’s PSC cell therapy pipeline. You will define and execute appropriate characterization, validation and tech transfer activities for differentiation manufacturing process throughout the product lifecycle. Cool Stuff! This role is based in Cambridge, MA and will require onsite leadership.

What you’ll do

  • Provide strategic and technical leadership in the development of innovative, scalable differentiation processes used for manufacturing of Sana’s PSC cell therapy pipeline
  • Provide strategic and technical leadership in the characterization, validation, tech transfer or oversight activities required to ensure successful execution of differentiation processes in GMP manufacturing, GLP tox studies, and GMP MCB generation including oversight of external CDMOs
  • Develop the content of relevant CMC sections of regulatory dossiers, supporting regulatory queries and inspections
  • Champion and drive technical innovations for scalable PSC manufacturing processes, either in bioreactors or adherent vessels, include both internal and external innovation through collaborations with academic research institutions and suppliers
  • Build strong collaborations across functions within Sana with Research, Development Sciences, and Tech Ops functions (process development, analytical development, quality and regulatory) to align activities to rapidly advance Sana’s PSC pipeline
  • Align with Platform Team Leader to ensure deliverables of the program are met and ensure successful execution of PSC gene editing, expansion, banking and differentiation processes in manufacturing
  • Actively engage in the scientific community to build the reputation and creditability to position Sana as a leader in the field
  • Build a world class team that will execute on the defined strategy
  • Develop and mentor a high-performing team of scientists and engineers with a vision of setting industry-leading scientific standards and innovation
  • Manage the functional component of business planning and own budget accountability for this group
  • As a member of the Tech Ops Cell Therapy Process Development Leadership Team, help develop the organization strategy, cultivate opportunities for innovation and career development, champion the Sana culture and make it a great place to work
  • Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
  • Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
  • Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment
  • Innate ability to assess talent that will help grow the organization and add to Sana’s culture 

What we’re looking for

  • PhD in a life Scientific Discipline or engineering filed with 15+ years of experience in academic research and/or industry
  • Expert knowledge of cell therapy process development principals and concepts and is a thought leader; has experience managing department(s) with senior employees
  • Current scientific knowledge of latest technologies in PSC process development, particularly scalable cell culture systems such as bioreactors, and DOE experience
  • Proven track-record of technical excellence and industry experience with PSC process development approaches as well as overall CMC product development
  • Demonstrated ability to successfully manage therapeutic programs throughout product life cycle from pre-IND through clinical development to commercialization stages
  • CMC team leadership experience – demonstrated ability in a fast-paced, multifaceted matrixed team environment, ability to comprehend the big picture and also strategically drive execution details for CMC deliverables
  • Knowledge and understanding of regulatory guidelines and working experience in a cGMP environment
  • Experience overseeing the transfer of a cell therapy process internally and externally for cGMP manufacturing
  • Ability to deliver results consistently and effectively
  • Ability to communicate across all levels of an organization and efficiently coordinate activities with both internal and external customers
  • High degree of self-motivation
  • Ability to quickly adapt to changing business conditions
  • Demonstrated track record in attracting and developing talent
  • Proven track-record of organizational leadership, functional buildup and management

What will separate you from the crowd

  • Experience with PSC single cell cloning, CRISPR-Cas9 gene editing (or equivalent) and/or reprogramming
  • Knowledge of islet biology

What you should know

  • The base pay range for this position at commencement of employment is expected to be between $275,000 and $325,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

How we work together

  • Lead from every seat – we seek to understand, act with honesty, and engage in the crucial conversations
  • Thrive as a team – we hire amazing people, are intensely curious, and cultivate inclusion and personal connectivity
  • Make it happen – we value vigorous debate, alignment around our decisions, and resilient execution 

Get to know us

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. For benefit eligible employees, we cover 100% of the cost for employee health coverage and offer generous time-off (various paid time off benefits, such as holidays, vacation, sick time, and parental leave), short- and long-term disability, employer paid basic life insurance, additional voluntary life insurance protection, financial wellness programs including financial planning resources, a 401(k) Plan with an immediately vested employer match, Tuition Reimbursement and Student Loan Repayment, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.  For more details on our benefits, visit Sana’s Benefits Portal.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, social class (including caste/caste identity), taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.


Sana Biotechnology, Inc. is focused on creating and delivering engineered cells as medicines for patients. We share a vision of repairing and controlling genes, replacing missing or damaged cells, and making our therapies broadly available to patients. We are a passionate group of people working together to create an enduring company that changes how the world treats disease. Sana has operations in Seattle, Cambridge, South San Francisco, and Rochester.

Company info
Sana Biotechnology
188 East Blaine Street, Suite 400
Seattle, WA 98102

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