Principal Scientist - Biotransformation

HOW MIGHT YOU DEFY IMAGINATION?

If you feel like youre part of something bigger, its because you are. At Amgen, our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing, and delivering ever-better products that reach over 10 million patients worldwide. Its time for a career you can be proud of.

Principal Scientist - Biotransformation

Live

What you will do

Lets do this. Lets change the world. In this role, you will be a part of the department of pharmacokinetics and drug metabolism (PKDM) within Amgen Research. This group is dedicated to the discovery and development of novel, effective, and safe medicines. The successful candidate will work in a team environment to characterize the absorption, distribution, metabolism, excretion, and pharmacokinetic properties of therapeutic drug candidates to achieve their full pharmacological potential. PKDM works in close partnership with subject areas such as medicinal chemistry, protein sciences, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology and regulatory to craft promising clinical therapeutic candidates, conduct preclinical development studies, support clinical evaluation, and contribute to IND and NDA filings.

Job Responsibilities:

The responsibilities of a PKDM Scientist are to develop and employ bioanalytical methods for the quantitative and qualitative analysis of small molecules and metabolites in plasma, tissues, and other biological matrices. The role will require data interpretation and communication of results to project team representatives in support of drug discovery and development.

• Experience on metabolite profiling/characterization in in-vitro and in vivo matrices using high resolution LC-MS/MS and/or metabolite identification software. Developing suitable assays for met id, reactivity etc. and strategies to support small molecule drug design and SAR. Identifying soft spots, metabolic pathways, and responsible drug metabolizing enzymes.
• Experience/familiarity in biosynthetic tools and approaches to synthesize metabolites for structure elucidation/confirmation and to use as standards is a preferred skill.
• Experience in biotransformation studies using radiolabeled compounds in various matrices is a preferred experience.
• Experience in study report writing to submit for regulatory filing of INDs and NDAs is preferred.
• Ability to execute experiments to quantitate molecular entities by mass spectrometry in support of both drug discovery and early development programs. Ability to assist in troubleshooting when instrument or assay problems arise.

Win

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a driven with these qualifications.

Basic Qualifications:

Doctorate degree with years of drug discovery and development experience or

Masters degree and 6 years of the relevant experience or

Bachelors degree and 8 years of the relevant experience

Preferred Qualifications:

• PhD or MS in chemistry, biochemistry, biophysics, medicinal chemistry, pharmacology or equivalent and 4+ years of drug discovery and development experience.
• Excellent oral and written communication skills and be able to excel in a highly collaborative, matrixed team environment. We understand that to successfully sustain and grow as a global enterprise and deliver for patients we must ensure a diverse and inclusive work environment.

Thrive

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for our teammates professional and personal growth and well-being.

The annual base salary range for this opportunity in the U.S. is $167,404-186,437.

In addition to the base salary, Amgen offers a Total Rewards Plan comprising health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities including:

• Comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts.
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans and bi-annual company-wide shutdowns
• Flexible work models, including remote work arrangements, where possible

Apply now

for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

careers.amgen.com

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.