Scientist

Job description

About the job

Company

RemeGen is a global biopharmaceutical company with headquarter in China and offices in San Francisco and Maryland in the United States. RemeGen is committed to the discovery, development, and commercialization of innovative and differentiated biologics to address major unmet medical needs. We have rich pipelines in Autoimmune, Oncology and Ophthalmology. Disitamab Vedotin (RC48) was approved to treat gastric and urothelial cancers in China and global Phase 3 clinical trials are in planning in partnership with SeaGen. Additional molecules are either in the clinical stage of development or entering to clinical in various Oncology indications. RC28 and other molecules are in clinical development in Ophthalmology diseases. Telitacicept (RC18) is our lead molecule in the Autoimmune diseases area.

Telitacicept is a first-in-class TACI-Fc fusion protein that targets both B-cell lymphocyte stimulator (BLyS) and A Proliferation Inducing Ligand (APRIL). Telitacicept was approved in China for SLE in 2021 based on the Phase 2 clinical trial results and received FDA fast-track status for development in SLE. Results from the Phase 3 clinical trial conducted in China, which was presented at ACR in November 2022, demonstrated consistent results, with a statistically significant treatment effect of SRI-4 response rate of 67.1% for RC18 vs. 32.7% for placebo (missing data imputed as non-responders). Other major milestones of Telitacicept include the Phase 2 and 3 clinical trials in China for Rheumatoid Arthritis, Primary Sjogren’s Syndrome, Myasthenia Gravis (MG), Lupus Nephritis, Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and IgA Nephropathy in China and US. In addition, we have received FDA orphan designation and fast-track status for MG global development.

Key Responsibilities

Responsibilities

• Identify the opportunities in immuno-oncology drug discovery and lead project.
• Design, develop and perform functional assays for target validation, therapeutic candidate evaluation, and lead selection to support immuno-oncology drug discovery pipeline.
• Continue improvement of the team capabilities by identifying and implementing new technologies and platforms for drug discovery and development to address critical project needs.
• Analyze/interpret data, maintain detailed and well-organized records of experiments.
• Present scientific results and write research report.
• Collaborate within and cross-functional groups promptly communicate the results.
• Stay current with emerging scientific literature and drug discovery trend.

Qualifications

· PhD with 5-8 years of research experience in oncology or immunology or molecular/cellular biology fields.

· Scientific and technical expertise in discovery research in oncology and drug discovery.

· Expertise in mechanistic studies of immune cell function in antitumor immunity.

· Expertise in design and performing flow cytometry-based characterization of immune cells.

· Expertise in cellular and molecular biology .

· Strong written and oral communication skills.

· Experience with antibody drug development and animal models of cancers is a plus.

· Experience with CRISPR/Cas9 gene editing technology and/or screening is a plus.

· Experience with Omics technologies (scRNA-Seq, spatial transcriptomics analysis, etc.) is a plus.

Preferred Qualifications

• Experience working in the biotech (Immunology/Oncology) related industry

Remegen Biosciences is an equal employment opportunities (EEO) employer.

Job Type: Full-time

Salary: $70,000.00 - $120,000.00 per year

Benefits:

• 401(k) and matching program
• Medical, Vision, and Dental Insurance
• Flexible Spending Account
• Short- and long-term disability
• Life insurance
• Employee Assistance Program
• Employee discounts
• Paid time off/vacation/sick time
• Professional development assistance
• Referral program

Schedule:

• Monday to Friday

Education:

• Doctorate (Required)

Experience:

• immunology/oncology: 5 years (Required)

Work Location: In person