Sr. Research Associate II, Biologics Analytical Operations

Sr. Research Associate II, Biologics Analytical Operations
United States - California - Oceanside

Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.

Making an impact on a global scale
Inclusion is one of the company’s five core values. That’s because we know that we are stronger and more innovative at Gilead when we are informed by a diverse set of backgrounds, experiences and points of view. Gilead Sciences is a biopharmaceutical company that discovers, develops and commercializes innovative therapeutics in areas of unmet medical need. The company's mission is to advance the care of patients suffering from life-threatening diseases worldwide.

When you join Gilead, you join our mission to change the world by enabling people to live healthier and more fulfilling lives. Come join a mission-driven bio-pharmaceutical organization that values inclusion and diversity, has a strong portfolio of products, and is constantly #CreatingPossible

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.


Job Description


Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, and cancer. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California

We are seeking a Sr. Research Associate II, Biologics Analytical Operations to join our rapidly growing Oceanside team. By joining Gilead, you will further our mission to address unmet medical needs and improve life by advancing the care of patients with life-threatening diseases.

Role Summary:

The successful candidate will be expected to demonstrate hands-on experimental responsibilities in the analytical laboratory. The role will develop and optimize potency bioassay (e.g. ELISA) or cell-based assay under supervision.

Role and Responsibilities:

• A good understanding of Bioassay method development (ELISA, Receptor Binding, Flow Cytometry, and Cell-based) for early and late stage biotherapeutics (mAbs, peptides, mRNA and antibody-drug conjugates) is required. The successful candidate will be expected to demonstrate hands-on laboratory experience.
• The candidate will contribute to developing and validating potency assays, confirming the potency of final drug substance and drug product, and supporting lot release and stability QC testing. The candidate will also participate in structure activity relationship work as part of a team to characterize the molecule, degradation pathways and define critical quality attributes in a phase appropriate context.
• Works with Gilead internal researchers in the identification and development of orthogonal characterization methods (e.g. Primary T cell activation, ADCC, ADCP) to support BLA-enabling studies. Responsible for production and maintenance of critical custom reagents and cell lines used in development and QC potency assays.
• The candidate should be able to plan/execute experiments and draw conclusions from study results with minimal supervision, able to propose next steps to supervisor for guidance. The candidate will regularly present data to team and potentially other AO groups. This is a highly collaborative environment where willingness and ability to communicate and work effectively with individuals across various project teams is essential.
• Candidates should be self-motivated and organized, proactively identifying issues and developing solutions in a collaborative multidisciplinary environment. The applicant is able to manage time independently while adhering to clear deadlines set by manager or project needs.

Essential Duties and Job Functions:

• Under general supervision, develop and validate potency assays to support biological drug development.
• Demonstrate hands-on experimental responsibilities in the laboratory including aseptic technique, routine cell culturing and performance of plate-based assays.
• Operates scientific equipment, selects appropriate methods and techniques to perform experiments, and prepare related reports. Plans and organizes details of experiments with guidance.
• Demonstrate good verbal communication skills and interpersonal skills. Be able to work in a fast-paced and highly collaborative working environment.

Knowledge, Experience and Skills:

• Hands-on experience of plate-based assay is a must. Practical experience of SoftMax pro software is a plus. Cell culture experiences will be a plus.
• Exercises independent judgment in developing methods, techniques and evaluation criteria for obtaining results. Demonstrates high attention to detail, ability to recognize anomalous and inconsistent results and interpret experimental outcomes. Demonstrates technical proficiency, scientific creativity, collaboration with others and independent thought in suggesting experimental design and research strategy.
• Experience with GMP validation and testing is preferred.

Basic Qualifications:

• BA or BS degree and 4+ years of experience in Pharmacology, Biology, Chemistry, Immunology or relevant scientific discipline OR MS degree and 2+ years of experience in Pharmacology, Biology, Chemistry, Immunology or relevant scientific discipline.
• Good communication skills (both verbal and technical) and interpersonal skills are required. Must be able to work in highly flexible and effective teams.

The salary range for this position is: $94,690.00 - $122,540.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.

For additional benefits information, visit:

https://www.gilead.com/careers/compensation-benefits-and-wellbeing

* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.

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As an equal opportunity employer, Gilead Sciences Inc. is committed to a diverse workforce. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact careers@gilead.com for assistance.

For more information about equal employment opportunity protections, please view the 'Know Your Rights' poster.

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Our environment respects individual differences and recognizes each employee as an integral member of our company. Our workforce reflects these values and celebrates the individuals who make up our growing team.

Gilead provides a work environment free of harassment and prohibited conduct. We promote and support individual differences and diversity of thoughts and opinion.

For Current Gilead Employees and Contractors:

Please log onto your Internal Career Site to apply for this job.






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