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Principal Scientist I/II, Clinical Biomarkers

Cambridge, MA
Start date
May 30, 2023

View more

Clinical, Clinical Research, Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time

Job Details

Schrödinger seeks a Principal Scientist I/II to join the Clinical Biomarkers team with expertise in discovery and development of phase appropriate biomarker and diagnostic assays to join our dynamic and multi-disciplinary Drug Discovery and Early Development team. This role will liaise with discovery and development project teams and functional area representatives focusing on biomarker discovery and feasibility assessment relevant to our clinical and regulatory strategies. The scientist will spend at least 50% of the time at the bench in our newly built clinical biomarker lab at Framingham, Massachusetts designing, developing and qualifying clinically applicable assays related to patient selection, target engagement, pharmacodynamic and mechanistic biomarkers. 

Who will love this job:

  • An experienced researcher with a proven track record of successfully developing and implementing  biomarker assays using a wide breadth of low and medium throughput assays and methodologies
  • An independent scientist with a keen eye for detail who’s worked on companion or complementary diagnostics
  • An energetic team player who enjoys working collaboratively in a fast paced environment across disciplines and is innately curious

What you’ll do:

  • Execute on clinical biomarker plans, including:
    • Partner with discovery biology scientists including computational biology team members to bridge preclinical PK/PD assay methodologies and read-outs to an executable clinical PK/PD assay, and develop pharmacogenomic hypotheses to guide indication selection and patient stratification in a rational and testable manner
    • Contribute to creation of regulatory and clinical documents including but not limited to Pre-IND and IND non-clinical pharmacology sections for lead clinical candidates, clinical protocols, investigator brochures, posters, publications
    • Develop/transferassays for clinical biomarkers to selected vendors and oversee assay development, fit-for-purpose validation, and assay report generation
    • Provide support in the oversight of bioanalytical assay scientist(s) at CROs
    • Partner with clinical operations scientists, clinical vendors, and biorepository to maintain sample chain of custody 

What you should have:

  • Experience in the biological or medical sciences (with a focus on oncology or immunology) - at least 10 years with an advanced degree (PhD, MD, or equivalent), 12 years with a Master’s degree or fifteen with a Bachelor’s degree; at least 3 years must be spent in an industry setting 
  • Strong experimental background and experience in hypothesis-driven biological/translational research with demonstrated ability to execute well-designed experiments in vitro/ex vivo using primary human cells and tissues
  • Familiarity with common clinical biomarker assay platforms, including spatial genomic, IHC, ELISA/MSD, other substrate-binding or target engagement methods and cell-based ex vivo assays
  • Experience developing clinical flow cytometry-based assays under GLP/GCLP/CLIA-like settings is a must 
  • Understanding of the requirements for fit-for-purpose, GLP-compliant, or CLIA-compliant assay validation, and experience applying these standards appropriately based on development stage and biomarker status in the program is preferred
  • Basic understanding of bioinformatics, NGS algorithms and methodology as it applies to clinical data is a plus

Pay and perks:

Schrödinger understands it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, stock options, and a wide range of benefits that include healthcare (with dental and vision), a 401k, pre-tax commuter benefits, a flexible work schedule, and a parental leave program. We have catered meals in the office every day, a company culture that is relaxed but engaged, and over a month of paid vacation time.  Our Administrative and Human Resources departments also plan a myriad of fun company-wide events. New York is home to our largest office, but we have teams all over the world. Schrödinger is honored to have been selected as one of Crain's New York Best Places to Work for the past three years running.

Sound exciting? Apply today and join us!

As an equal opportunity employer, Schrödinger hires outstanding individuals into every position in the company. People who work with us have a high degree of engagement, a commitment to working effectively in teams, and a passion for the company's mission. We place the highest value on creating a safe environment where our employees can grow and contribute, and refuse to discriminate on the basis of race, color, religious belief, sex, age, disability, national origin, alienage or citizenship status, marital status, partnership status, caregiver status, sexual and reproductive health decisions, gender identity or expression, sexual orientation, or any other protected characteristic. To us, "diversity" isn't just a buzzword, but an important element of our core principles and key business practices. We believe that diverse companies innovate better and think more creatively than homogenous ones because they take into account a wide range of viewpoints. For us, greater diversity doesn't mean better headlines or public images - it means increased adaptability and profitability.


Schrödinger is a leading provider of advanced molecular simulations and enterprise software solutions and services to accelerate and increase the efficiency of drug discovery for its clients, which include all major pharmaceutical and biotechnology companies worldwide, as well as leading materials science researchers. Schrödinger also establishes deep partnerships and collaborations with companies in such fields as biotechnology, pharmaceuticals, chemicals, and electronics, and was a co-founder of leading biotech companies including Nimbus Therapeutics, Morphic Therapeutic, and others. Through significant long-term investments in basic research, Schrödinger has made scientific breakthroughs across many areas of drug discovery and materials science.

A great company is made up of great people, and Schrödinger is no exception. Whether you’re in Administration, Sales, Finance, Law, Engineering, IT, or Science, we are always on the lookout for exceptional candidates who can join us and make our team stronger. You will find Schrödinger to be a dynamic, energetic, and fast-paced place to work, where you get to interact with some of the smartest and hardest working people you’ll ever meet. If you’ve ever had a curiosity about science, and how science can improve people’s lives, then there’s no
better place to be than Schrödinger.

Stock Exchange: NASDAQ

Stock Symbol: SDGR


Company info
120 West 45th Street
17th Floor
New York

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