Scientist II, Precision Medicine Immuno-Oncology

The Precision Medicine organization within AbbVie is committed to advancing drug development and patient care through building a deep understanding of disease biology and developing tools to optimize clinical decision making and customize treatment for patients. The Translational Immuno-Oncology (I-O) group within Precision Medicine Oncology department uses advanced technologies to study cancer immunology, discover biomarkers and validate mechanisms of action of AbbVie’s innovative I-O oncology pipelines to inform clinical decisions including indication/patient selection, and combinations.  

We are seeking a highly motivated and experienced scientist with a strong background in immunology/IO and a proven track record of research accomplishments to join this dynamic team.  The successful candidate will work both within the Translational I-O group and as a member of cross-functional interdisciplinary teams. The candidate is expected to design and execute experiments independently to enhance our translational and biomarker research for the I-O pipelines.

Key Responsibilities include:

• Independently investigate, identify, develop, and optimize new methods/ techniques to address critical project needs.
•  Proficiency in standard cellular and molecular techniques, and strong technical skills in performing multiparameter flow cytometry and data analysis.
• Continuously seek to improve existing laboratory methods and processes. Read and adapt literature to accomplish assignments.
• Demonstrate mastery of broad range of experimental techniques and methods of data analysis.
• Generate reliable and reproducible data in a timely manner. Analyze, interpret, and draw conclusions independently. Generate reports and present data to the team.
• Initiate and maintain collaborations with cross-functional teams such as Discovery, in-vivo pharmacology, Pathology/CDx, bioinformatics, DMPK and others to ensure alignment on scientific rationale and data generation workflows.

Basic Qualifications:
•    BS degree with 7+ years or MS degree with 5+ years in cancer immunology or a related discipline. 
•    Experience with immune cell-based assays including flow cytometry, cytokine secretion (bead based) assays, cell proliferation assays, NK, or T cell killing assays, and ELISA.
•    Perform routine molecular and cellular assays, cell culture and bioassays such as luciferase-based assays.
•    Analyze data using biological and statistical software such as Flowjo, Prism, Excel, etc
•    Demonstrated effective interpersonal and written/verbal communication skills.
•    Good general laboratory and organizational skills and proven ability to work successfully in a team environment.
•    Demonstrated critical thinking skills as well as excellence and productivity in independent research.
•    Must be proactive and able to work effectively on multiple projects in a fast-paced, dynamic multidisciplinary research team.

Preferred Qualifications: 
•    MS degree with 6+ years in cancer immunology or a related discipline
•    Ability to design and develop tailored flow cytometry panels and execution of these panels on flow machines such as BD symphony and Cytek aurora is highly desirable. 
•    Experience in biomarker assessment with platforms such as MSD, Nano String, and O-link assays.
•    Hands-on skill set in designing and performing complex ex-vivo experiments using fresh human tumor tissue samples such as 3D culture of immune cells and cancer cells.
•    Expertise in human immunology, tumor immunobiology or prior exposure to translational research/biomarker discovery is a plus.
•    Knowledge of analytical software for routine data analysis, and exposure to AI based high throughput analysis platforms, such as OMIQ is desirable. 

**Equal Opportunity Employer Minorities/Women/Veterans/Disabled**

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.