This job has expired

You will need to login before you can apply for a job.

Scientific Director/Sr. Director of Upstream Process Development

Eli Lilly and Company
Indianapolis, Indiana
Start date
May 27, 2023

View more

Engineering, Manufacturing & Production, Process
Required Education
Position Type
Full time
Best Places to Work

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Bioprocess Research and Development team has an exciting opportunity for an innovative scientist, technical expert to join our process development organization. You will be part of a diverse team of biochemists, biologists, chemical engineers, and analytical chemists to develop Lilly’s growing portfolio of therapeutic products and various modalities (AAV gene therapy products, mAb, fusion proteins, bioconjugates and etc.) at all stages of development.

The Director/Sr Director of Upstream Process Development will be responsible for drug substance process development of AAV-based gene therapy products and/or other products in Lilly’s biologics pipeline.  The Director/Sr Director of Upstream Process Development is responsible for leading a team of scientists & engineers responsible for developing and improving the manufacturing processes for biologics pipeline and clinical phase programs. The successful candidate will leverage their deep knowledge of bio process development to advance the platform processes and contribute to advancing the portfolio. The successful candidate will also exhibit a strong commitment in employee development and thrive in a collaborative, scientifically stimulating, and fast-paced work environment.


  • Lead a team of scientists and engineers responsible for upstream process development activities (process design, optimization, characterization, scale-up, scale-down model, technology transfer, process troubleshooting) enabling a diverse biologics portfolio through early- and late-stage clinical development.

  • Advance upstream platform process technical strategy and capabilities for different modalities especially AAV gene therapy products; drive and define creative process improvement initiatives, lead a team to deliver innovations that advance technical capabilities, improve process yield, robustness, scalability for AAV production.

  • Author and review CMC documentation including CMC sections of regulatory submissions, technical reports to support filing and responses to regulatory agency questions

  • Serve as an upstream development subject matter expert, provide technical direction for process development, characterization, and commercialization activities to ensure a smooth and clear path to successful regulatory submissions for the portfolio.

  • Foster strong cross-functional collaborations within Development organizations; and effectively collaborate with other groups in Discovery and Manufacturing as well as external partners to develop products and new technologies.

  • Supervise, coach and mentor junior scientists, engineers.

Basic Qualifications

  • PhD in Chemical Engineering, Bioprocess Engineering, Biology, Biochemistry, Chemistry, or related field with 8+ years of industry experience

Additional Skills/Preferences:

  • Experience in CMC development, manufacturing and compliance requirements from early to late clinical phase programs

  • Subject matter expertise in upstream process development, including extensive hands-on experience with cell culture process development.

  • Strong understanding of industry and academic trends and innovative technologies in AAV process development

  • Expertise with variety of cell culture processing platforms and production systems (mammalian, insect, bacterial).

  • Upstream process development experience for viral vectors in an industry setting

  • Proven ability to work cross functionally, effectively plan and organize work activities and prioritize to meet schedules and deadlines

Additional Information

  • Location: Indianapolis, IN

  • Travel: Up to 5%

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.


Get job alerts

Create a job alert and receive personalized job recommendations straight to your inbox.

Create alert