Sr. Scientist I, II, Principal Scientist, Computational Chemistry

Sr. Scientist 1/Sr. Scientist II, Principal Computational Chemist

This position will support the research project team with computational chemistry for drug discovery project(s). They will also help create intellectual property for small molecule inhibitors through the identification of critical interactions between our inhibitors and target enzymes. In addition, this person will oversee our drug discovery database management systems and evaluate our in-house and external screening libraries against our GPCR and MASP targets.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Who is Omeros? 

 
Omeros is an innovative biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, immunologic diseases
(e.g., complement-mediated diseases) and cancers. Omeros’ lead MASP-2 inhibitor narsoplimab targets the lectin pathway of complement and is the subject of a biologics license application pending before FDA for the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy. Narsoplimab is also in multiple late-stage clinical development programs focused on other complement-mediated disorders, including IgA nephropathy, atypical hemolytic uremic syndrome and COVID-19. OMS906, Omeros’ inhibitor of MASP-3, the key activator of the alternative pathway of complement, is in a Phase 1 clinical trial. For more information about Omeros and its programs, visit www.omeros.com.

What are you Responsibilities?

• Contribute to small molecule lead discovery programs and actively implement cheminformatic tools
• Oversee drug discovery database management systems, including data mining and statistical evaluation
• Guide compound design on multiple projects, interfacing with medicinal chemistry, structural biology, and assay group
• Compound property and diversity analysis of high throughput and focused screening libraries
• Develop new approaches for designing relevant chemical features using scoring functions, statistics and machine learning
• Work closely with medicinal chemistry and biology to develop tools to better understand structure activity relationships
• Operate, maintain, and develop PC- and server-based computational software packages
• Analyzes, prepares and presents data.
• Ensures safety standards are maintained.
• Manages and archives data.
• Presents scientific results effectively.
• Maintains a safe working environment.
• Attends project meetings as appropriate.
• Performs other duties and responsibilities as required.

Experience and Education Required:

• Requires a Ph.D. (or equivalent) in chemistry with relevant experience in small molecule cheminformatics, or a Ph.D. in cheminformatics with experience in medicinal chemistry
• 1-5 years of industry experience
• Demonstrated proficiency in using MS Office applications is required
• Ability to work effectively under pressure, handling multiple priorities simultaneously, is essentia
• Excellent written and verbal communication skills and time management skills are required, as are a team oriented and highly motivated demeanor

Behavioral Competencies Required:  

• Ability to build and maintain positive relationships with management, peers, subordinates is essential.  
• Must display strong analytical and problem solving skills and attention to detail.  
• Must have integrity.  

Physical Demands Required:

•  This position requires intermittent physical activity including bending, reaching, pushing, pulling, or lifting, up to 40 lbs., and prolonged periods of sitting or standing.  
•  This position requires working around hazardous material.

Compensation and Benefits:

Omeros is proud to offer a competitive total compensation package designed to support the lives of our employees and their families. The wage scale for the Sr Scientist I it's $135,000 - $153,000 per year.  For the Sr Scientist II it is $162,000 - $183,000. And for the Principal Scientist it's $180,000 - $202,000

Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to  hr@omeros.com   or contact Omeros, asking for Human Resources, at (206) 676-5000