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Sr. Scientist, Analytical Chemistry (LC/MS)

Regeneron Pharmaceuticals, Inc.
Tarrytown, New York
Start date
May 25, 2023

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Job Details

We are seeking a highly motivated Sr. Scientist to join the Analytical Chemistry Group of Regeneron Pharmaceutical Inc. at Tarrytown, NY.

The Sr. Scientist will be working in an innovative liquid chromatography and mass spectrometry (LC/MS) lab, developing and performing top-down and bottom-up mass spectrometry with the state of art LC-MS instruments for therapeutic drug characterization. In this role, you will focus on the biochemical characterization of therapeutic proteins at all stages of development. You will develop and implement LC/MS based methods for protein primary structure elucidation. This will include peptide mapping, disulfide linkage determination, carbohydrate profiling, and post-translational modifications, sequence variant analysis.

A day in the life of a Sr Scientist may look like:
  • Develop primarily LC/MS based analytical methods to support the development of monoclonal antibody-based therapeutic proteins, bispecific antibodies, Fc-fusion proteins, and other modalities (adeno-associated virus, mRNA, siRNA, etc.).
  • Conduct analytical experiments and analyze LC-MS data to elucidate the quality attributes of therapeutic protein candidates, drug products and critical reagents.
  • Develop LC-MS based bioanalytical strategies and high-throughput methods for quantitation of different types of drug candidates, including small molecule, peptides, oligonucleotides, monoclonal antibody, antibody-drug conjugate and other alternative novel modalities in biological matrices to support preclinical and early-stage clinical PK study.
  • Explore novel analytical and bioanalysis technologies and emerging platforms to meet the needs of an evolving portfolio that may include novel molecular modalities and new therapeutic area.
  • Collaborate with therapeutic function areas to support drug discovery.
This may be the right role for you if you have:
  • Strong organizational and communication skills and effective interpersonal skills.
  • The ability to learn new technologies fast with good problem-solving skills.
  • Enthusiasm in science with a motivation of making contributions in a team environment.
In Order to be Considered Qualified for this role you must have:

A Ph.D. in analytical chemistry, biochemistry, pharmaceutical sciences or a related field and 0-5 postdoctoral experience, or a MS degree with 5+ year experience or a BS degree 7+ of relevant experience. Required experience should include liquid chromatography and mass spectrometry, with proven track record of successfully developing MS, LC-MS or LC-MS/MS methods. Familiarity with sophisticated liquid chromatography mass spectrometry technologies and relevant software for data analysis is also required.


Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00


Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.

Stock Symbol: REGN

Stock Exchange: NASDAQ

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Corporate Headquarters
777 Old Saw Mill River Road
New York
United States

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