Director-Molecular Pharmacology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Lilly is passionate about the discovery, development and commercialization of potential new medicines that will impact and improve the lives of patients. Do you have expertise in molecular pharmacology and want to bring a new perspective to drug discovery? Apply today and join the Lilly family!

Our Molecular Pharmacology team is an innovation-focused organization using groundbreaking technologies to deliver maximum benefit to our patients. We are looking for a scientist who will work collaboratively to help us discover small molecule therapeutics for disease targets. You will work with experts in pharmacology, biophysics, bioanalytical, chemical biology, medicinal chemistry, structural biology, and disease biology to discover and optimize molecules for human testing.

• Lead a small group of in vitro pharmacologists to enable targets for small molecule discovery. Partner with therapeutic biology leaders in diabetes, immunology, or neurodegeneration to build disease relevant assays.
• Strong depth of expertise in cell signaling transduction mechanisms and methods to understand them. Ability to supervise scientists with a variety of expertise including receptor pharmacology and biochemistry.
• Integrate biochemistry, biophysics, cell biology, bioanalytical methods, chemoproteomics, and chemical biology to discover medicines with differentiated pharmacology. Form strong collaborations with structural biology, medicinal chemists, computational scientists, and ADME/tox leaders.
• Lead teams in the identification of small molecule ligands suitable for optimization by medicinal chemistry teams.
• Build in vitro assay solutions and generate data to identify the clinical exposure requirements for target engagement and efficacy.
• Engage internal/external resources and transformative leaders. Advance and complement internal capabilities that drive lead generation efforts.
• Embrace diversity of thought, backgrounds, and experience to deliver creative solutions.

• Ph.D. in cell biology, pharmacology, chemical biology, biochemistry or closely related field.
• 6 years of experience preferably in a biotech or pharmaceutical setting
• Demonstrated track record for publication and presentation of research results.

• Knowledgeable of small molecule strategies to drug challenging targets (e.g. covalent drugs, targeted protein degradation, molecular glue, bifunctional/bimodality approaches, RNA splicing modifiers)
• Continue to learn and practice the science of drug discovery with input from scientists at all levels in the organization.
• Contribute to scientific projects where solutions are developed through teamwork.
• Knowledgeable of how to balance pragmatism with risk taking in the pursuit of solving difficult scientific problems.
• Possess strong communication (oral, written), organizational, and leadership skills.
• A passion for mentoring and developing future scientific leaders

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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