Senior Research Scientist I, Drug Metabolism and Pharmacokinetics (PK Modeling)
United States - California - Foster City
Gilead Sciences, Inc. is a research-based bio-pharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical need. With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead’s therapeutic areas of focus include HIV/AIDS, liver diseases, cancer and inflammation, and serious respiratory and cardiovascular conditions.Making an impact on a global scale
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Gilead Sciences, Inc. is a research-based biopharmaceutical company headquartered in Foster City, California, that discovers, develops and commercializes innovative medicines in areas of unmet medical need.
Together, We're Creating What's Possible! For more than 35 years, Gilead has pursued breakthroughs that were once thought to be impossible.
With each new discovery and investigational drug candidate, we seek to improve the care of patients living with life-threatening diseases around the world. Gilead's therapeutic areas of focus include HIV, liver diseases, serious respiratory and cardiovascular conditions, cancer and inflammation.
The Drug Metabolism and Pharmacokinetics (DMPK) group at Gilead Sciences is seeking a candidate for the position of Senior Research Scientist. The successful candidate will serve as a subject matter expert for DMPK and PK/ PD M&S in biologics discovery and development projects. This person will work closely with other teams including biologics discovery, toxicology, clinical pharmacology, pharmaceutical sciences, and regulatory to ensure optimal leads and successful clinical evaluations. The title of the position will be commensurate with the candidate's experience.Essential Duties and Job Responsibilities:
Knowledge, Experience and Skills:
- Represent the DMPK group as a subject matter expert in biologics discovery and development projects
- Develop and execute PK/PD and M&S strategies that align with the molecule format, MOA, and indications
- Perform quantitative PK/PD analysis to support project deliverables and answer translational questions
- Collaborate with project teams, line management, and CROs to deliver high-quality reports for regulatory submissions
- Supervising of research scientists and associate scientists may be required.
- PhD in pharmacokinetics, drug metabolism, pharmacology/toxicology, immunology, bioengineering, or a related life science field with 2+ years of experience, or a MS degree with 8+ years of relevant experience in large molecule/biologics discovery and development
- Industry experience as a DMPK representative, and demonstrate proficiency in mechanistic and/or QSP PK/PD modeling and simulation
- Strong communication skills and the ability to interpret results, determine next steps, and present data effectively to project teams and senior management
- Proficiency in using routine PK and basic compartmental modeling software systems such as Phoenix/WinNonlin, ADAPT, MATLAB/Simbiology, or similar.
The salary range for this position is: $160,820.00 - $208,120.00. Gilead considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus, discretionary stock-based long-term incentives (eligibility may vary based on role), paid time off, and a benefits package. Benefits include company-sponsored medical, dental, vision, and life insurance plans*.
For additional benefits information, visit: https://www.gilead.com/careers/compensation-benefits-and-wellbeing
* Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans.
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