General Company Description
RESILIENCE (National Resilience, Inc.) is a first-of-its-kind manufacturing and technology company dedicated to broadening access to complex medicines and protecting biopharmaceutical supply chains against disruption.Founded in 2020, the company is building a sustainable network of high-tech, end-to-end manufacturing solutions to ensure the medicines of today and tomorrow can be made quickly, safely, and at scale. RESILIENCE will offer the highest quality and regulatory capabilities, and flexible and adaptive facilities to serve partners of all sizes. By continuously advancing the science of biopharmaceutical manufacturing and development, RESILIENCE frees partners to focus on the discoveries that improve patients’ lives.
For more information, visit www.resilience.com.
In this position, you will play a key role in supporting discovery and understanding of quality attributes for cell-free protein synthesis (CFPS) process development, and analytical development and characterization of biotherapeutics at Resilience. You will work with our scientific and engineering team to analyze critical input materials, cell-free extract and reaction, intermediates, and drug substances using LC-MS (Orbitrap, QTOF, Triple Quad), biophysical assays such as DLS and SEC-MALS methods, endotoxin, and bioburden assays, UPLC, capillary electrophoresis, immunoassays including ELISA and Western blots. The ideal candidate will have deep experience in developing these assays as well as data analysis and interpretation to provide insight into the cell-free process development. This role requires excellent communication and flexibility, backed by a high level of velocity and rigor.
Develop and utilize LC-MS multiomics platforms to enable discovery of quality attributes for development and quality control of cell-free protein synthesis process.
Characterize raw materials, cell lysate, cell-free reaction, intermediates using LC-MS systems.
Develop methods to characterize drug substances using DLS/SEC-MALS methods, endotoxin and bioburden assays, LC-MS intact protein and peptide mapping/PTM analyses, UPLC, capillary electrophoresis, immunoassays including ELISA and Western blots.
Set analytical strategy, and coordinate/perform in-house and outsourced analytical development and characterization.
Author analytical method SOPs and qualification protocols/reports.
Provide technical expertise on analytical methods for biotherapeutic drug substances.
Minimum Experience, Education, Qualifications, and Other Ideal Personal Characteristics
PhD in Analytical Chemistry, Biochemistry, Biotechnology, or related fields.
4+ years’ experience in analytical development for the pharmaceutical/biotech industry.
Hands-on experience with quantitative and discovery-based LC-MS multiomics workflows.
Direct experience with a wide variety of analytical methods including DLS/SEC-MALS methods, LC-MS intact protein and peptide mapping, UPLC, immunoassays including ELISA and Western blots, endotoxin, and bioburden assays.
Excellent command of English (written and oral) and strong communication and interpersonal skills.
Must be highly disciplined and organized, self-motivated and enthusiastic about taking a hands-on approach to collaborative scientific discovery efforts.
Availability to work full-time hours at our Oakland, CA location.
Resilience offers employees a robust total rewards program including equity, an annual cash bonus program, a 401(k) plan with a generous company match and our benefits package which is thoughtfully designed to support our employees with great healthcare (including medical, dental and vision), family building benefits, life and disability insurance, flexible time off, paid holidays, other paid leaves of absence, tuition reimbursement and support for caregiving needs. Our target annualized base pay hiring range for this position is $135,000.00 - $168,750.00. Actual base pay is dependent upon a number of factors, including but not limited to, the candidate’s geographical location, relevant experience, qualifications, skills and knowledge. Excited about Resilience and the biomanufacturing revolution? We encourage you to apply and start a conversation with one of our recruiters.