Sr Scientist, Assay Development

We are seeking a highly motivated Sr Scientist to join the Assay Development Group of Regeneron Pharmaceuticals, Inc. located at Tarrytown, NY. In this role, you will innovate mass spectrometry method development and implementation of validated mass spectrometry bioanalytical methods to support our diverse portfolio.

A Typical Day Might Look Like:

• Collaborate with established team of mass spectrometry and ligand-binding assay scientists to develop LC-MS/MS-based pharmacokinetic and biomarker assays in biological matrices for a diverse pipeline of novel biotherapeutics, including monoclonal antibodies, bispecifics, antibody-drug conjugates (ADC), adeno-associated virus (AAV), RNA and drug target biomarkers to support non-clinical and clinical studies.
• Drive innovative LC-MS/MS bioanalytical strategies, method development and validation to support various therapeutic modalities from early preclinical throughout clinical stages.
• Provide support for CRO outsourcing efforts for cross-functional teams and serve as a subject matter authority for troubleshooting, review of protocols and validation reports and data interpretation. Provide scientific monitoring of outsourced LC-MS bioanalytical assays and review bioanalytical data.
• Support efforts for expansion of in-house mass spectrometry technologies and capabilities for regulated bioanalytical methods.
• Participate in multi­disciplinary meetings such as joint project teams as Assay Development representative to help direct drug development programs. Collaborate closely with colleagues and partners. Draft or edit bioanalytical assays sections for IND and BLA submissions.

This Role Might Be For You If You:

• Stimulates, develops, and promotes the scientific and career development of direct and indirect reports.
• Can act as a leader within the group that effectively drives projects forward to meet ambitious timelines
• Can communicate efficiently with supervisor and other members within the company and/or outside vendors to acquire assay-related reagents or discuss reagents needs.
• Propose innovative solutions and troubleshooting to address scientific complexity and challenges.

This role requires PhD in chemistry, or biochemistry with a minimum of 0-3+ , a MS with 5+ or a BS with 7+years of proven experience, and a record of publications in the field. Expertise in LC-MS/MS and immunoassays with biopharma experience in the bioanalytical evaluation of protein therapeutics is a must; knowledge of AAV- and oligonucleotide-based therapeutics is desired. Hands-on experience that encompasses the entire workflow for quantitative protein analysis by LC-MS including peptide selection, protein extraction and immunocapture LC-MS/MS approaches in various matrices (serum, blood and tissues).In-depth knowledge of triple-quadruple MS systems a must; experience with other mass spectrometry systems desirable. Understanding of GLP and GCP requirements and industry practices of regulated bioanalysis; experience writing and reviewing SOPs. Experience with LC-MS bioanalytical assays a plus.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00