Advisor/Sr. Advisor - Oligonucleotide Characterization

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. For more than 140 years, we have worked tirelessly to discover medicines that make life better. These discoveries start in Lilly Research Laboratories, where our scientists work to create new medicines that will help solve our world’s greatest health challenges.

Responsibilities:

• Be the analytical lead with strong hands-on experience and detailed knowledge of oligonucleotides.
• Design & implement semi-preparative, analytical HPLC, LC-MS/LC-HRMS, CD, and fluorescence spectroscopy and other methods to characterize the oligonucleotides and oligonucleotide conjugates.
• Perform method troubleshooting as well as various data analysis, and operate instruments (Thermo, Shimadzu, Agilent, Waters, ets) associated software. Strong technical problem-solving abilities.
• Operate, maintain & calibrate analytical instruments.
• Be the go-to person for analytical support in the multiple disciplinary environments.

Basic Requirements:

• Ph.D. in Chemistry, Analytical Chemistry, Organic Chemistry, Biochemistry, Biochemical or Chemical engineering or related discipline with 2-5+ years of oligonucleotide experience, preferably in an industrial drug discovery setting.

Additional Skills/Preferences:

• Strong knowledge of nucleic acids chemistry, and oligonucleotide analytical techniques.
• Expertise in separation science, including but not limited to RP, HILIC, HIC, IEX, SEC and CE.
• Expertise in mass spectrometry including ESI ionization with a range of mass spectrometer designs (QToF, Orbitrap, QQQ).
• Experience in UV-vis, CD and fluorescence-based assays for oligonucleotide analysis
• Highly self-motivated and self-driven attitude with the ability to own and drive projects into success.
• Strong organizational and communication skills and effective people skills.
• Capable of continuous learning, open-minded, highly organized, and detail oriented.

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