Process Development Engineer I, Gene Therapy Purification Development

Regeneron’s Viral Production Core is looking for a Process Development Engineer focusing on gene therapy purification process development. In this role you will work as part of a multi-functional team to generate Adeno-Associated Virus (AAV) manufacturing processes and products with the aim of providing treatment to unmet medical needs through gene therapy. This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institutional knowledge gained from working for an established biopharmaceutical company.

A Typical Day in the Role Might Look Like:

• Support downstream viral vector process development and production through design, characterization, and implementation of robust purification processes suitable for future GMP clinical production.
• Optimize parameters for purification of AAV-derived viral vectors using multivariate design of experiment approaches and write development reports for characterized unit operations.
• Document experiments, results, and findings in electronic laboratory notebook and LIMS; present work at group and department meetings. Maintain equipment and solve instrumental/experimental problems.
• Reads and understands scientific literature and user documentation and implements experimental plans to verify literature findings.
• Develop expertise in theory and practice of manufacturing steps and analytical methods.
• Cross-train on and provide support for analytical and upstream operations.
• Support weekend or off-hour experimental and pilot scale work, as required.

This Role Might Be for You If:

• You have strong initiative to complete ambitious tasks and learn new technologies.
• You are capable of multi-tasking, thinking critically, working both independently and within a team environment.
• Have excellent interpersonal, verbal, and written communication skills.

This position requires a Bachelor’s degree in either Chemical Engineering, Biochemical Engineering, Biochemistry, or related field with 3-5 years meaningful experience, or Master’s Degree with 0-3 experience. The extent of the candidate’s prior experience will determine the grade of the position. A strong fundamental understanding of the principles of purification process development and a history of developing downstream steps within bioprocesses is a plus. Experience preferred with some of the following systems : Depth filtration, Tangential flow filtration, Affinity Capture chromatography, Polishing chromatography. Prior experience with producing AAV-based gene therapies is a plus. This job will periodically require short duration physical exertions, including light-medium lifting.

YouTube Video on PMPD Viral Production Core:

https://www.youtube.com/watch?v=KtR5_mKkXlo&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=1

YouTube Video on Diversity Equity & Inclusion in PMPD:

https://www.youtube.com/watch?v=BEORUD_Fnjk&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=3

YouTube Video on Career Development at Regeneron:

https://www.youtube.com/watch?v=4fg18hC-gsw&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=2

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Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$75,700.00 - $123,500.00