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Senior Director/Executive Director Clinical Development, Oncology

Arvinas Inc.
Hybrid, New Haven - Headquarters
Start date
May 12, 2023

View more

Clinical, Clinical Development, Clinical Research
Required Education
Position Type
Full time
Pharm Country

Job Details

Arvinas is a clinical-stage biotechnology company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being co-developed and commercialized by Arvinas and Pfizer as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 400 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit


Position Summary

This role will be a critical link with investigators and key opinion leaders in the external prostate cancer community.  The selected candidate will work closely with these experts, developing the clinical trial strategy, designing clinical trials, and identifying appropriate investigators for the bavdegalutamide (ARV-110) and ARV-766 studies. This individual will serve as a key strategic and medical point person during the conduct of the trials, monitoring safety of ongoing trials and leading efforts to analyze and present data from clinical studies. The selected candidate will work closely with the leadership team, scientists, regulatory professionals, statisticians, and members of the clinical operations department to carry out these responsibilities. The individual will respond to inquiries by practitioners and investigators, IRBs, regulatory bodies, and vendors. This person will work to establish relationships with key opinion leaders, external advisors and collaborators.

This position reports to our Chief Medical Officer and will be located at our headquarters in New Haven, CT. Hybrid work arrangements are possible.


Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Collaborates with leadership team, scientists, regulatory professionals, biostatisticians, regulatory, executive staff and others as necessary for development of clinical development strategy and clinical protocols, and analysis of data from these trials and trials with other molecules.
  • In collaboration with ARVINAS clinical operations staff, consultants and CROs, supports clinical trial execution to achieve timely completion of clinical studies.
  • Assumes medical responsibility for clinical programs. Actively participates in real-time medical monitoring of studies, including assessment of patient eligibility and responses to study design questions.
  • Provides safety monitoring of active clinical studies in collaboration with CRO and pharmacovigilance group.
  • Collaborates with associates (and/or consultants) in Regulatory, CMC, Toxicology, Research, Pharmacology to progress clinical compounds from Phase 1- 3 clinical development, in a project team setting.
  • Participates in clinical study report writing and review, using his/her medical expertise to identify ways to best analyze and present data in a complete, accurate and scientifically sound manner.
  • Collaborates with Principal Investigators in the evaluation and assessment of publications (abstracts, posters, manuscripts) associated with clinical data.
  • Other responsibilities that may apply, as periodically assigned by Chief Medical Officer.
  • Presents to the leadership team on clinical development program status and future strategy as appropriate.  


  • Must have clinical development experience in oncology. Solid tumor experience required; Prostate cancer experience preferred.
  • Strategic thinker with ability to provide input to clinical development plan.
  • Requires strong technical/analytical skills to identify and solve problems.
  • Must be self-motivated and confident with the ability to act with urgency and passion.
  • Proven ability to work with a high level of integrity, accuracy, and attention to detail is required.
  • Requires strong organizational skills in order to maintain a high level of productivity, innovation, and priority-setting in order to complete assignments on-time and on-budget.
  • Must have excellent oral and written communication skills for effectively interfacing with all levels of management and departments within the company.
  • The ability to make thoughtful, integrated, timely and meaningful decisions and take corresponding actions is required.
  • Must have willingness to work collaboratively by incorporating diverse perspectives and appropriately managing relationships in order to strengthen decision-making.
  • Must proactively seek out and recommend process improvements.
  • Must be resourceful, creative, enthusiastic, and results-oriented.
  • Must be entrepreneurial and enjoy working in a fast-paced, small company environment.
  • Successful academic research publication history or history of medical practice in a relevant field is required.
  • Requires experience presenting medical data and concepts to a variety of audiences (medical, scientific, vendors) in a credible and engaging manner.
  • Solid understanding of the clinical landscape relevant to oncology patients and health care practitioners in the field is required.
  • Requires demonstrated application of critical thinking skills to problem solving, data analysis, and strategic planning.
  • Must have a high degree of emotional maturity and can work successfully in a demanding environment while constantly maintaining a professional demeaner.


  • A Doctor of Medicine degree (MD) or equivalent is required.
  • A MD/PhD is preferred.


Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity Employer   


At Arvinas, we’re leading the creation of an entirely new way to treat disease through therapies that target and degrade disease-related proteins. We are a clinical-stage biopharmaceutical company focused on developing new therapeutics for cancers and other difficult-to-treat diseases. Our proprietary PROTAC® protein degraders, or proteolysis-targeting chimeras, work by harnessing the body’s own natural protein disposal system to degrade and remove disease-causing proteins.

Our leading programs are focused on high-value targets in cancer, including the androgen and estrogen receptors associated with prostate and breast cancers, respectively. Our hope is to unlock the full potential of PROTAC protein degradation by developing our own robust pipeline and by partnering with the world’s leading drug development companies.

Designed with health and wellness in mind, employees and their families are eligible for:

  • Medical, dental, and vision options, including a generous company contribution into an HSA
  • Paid maternity and paternity leave
  • FSA, HSA, Healthcare, and Dependent Care accounts
  • Company provided life insurance and short/long-term disability coverage
  • Additional voluntary benefits including critical illness, hospital care and more

Central to our organization is attracting, retaining and engaging the best and brightest by sharing in the success of our organization:

  • Competitive salaries and an annual incentive program
  • 401K matching program with immediate vesting
  • Eligibility for long-term equity incentives upon hire and annually

We believe it’s important to relax, unwind and enjoy life’s moments:

  • Paid vacation
  • A year-end office closure
  • Observed company holidays
  • Paid sabbatical upon 5 years’ tenure

We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. We take our work very seriously, but we also ensure we’re having fun while doing it. We embrace the freedom to pursue innovation, think creatively, and give back. We care about each other, celebrate our accomplishments, and rise up to encourage our colleagues through challenges. If you think one of these open positions might be a fit, we’d love to hear from you.

Find Us
5 Science Park
395 Winchester Ave
New Haven

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