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Sr Scientist I Pharmacology

South San Francisco, California
Start date
May 4, 2023

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Science/R&D, Biotechnology, Pharmacology
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay, Best Places to Work

Job Details

Oncology is a key therapeutic area for AbbVie, with a portfolio consisting of three marketed products — Imbruvica, Venclexta, and Empliciti — and a pipeline containing multiple promising new molecules that are being studied in nearly 200 clinical trials in 19 different types of cancer. More than 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work across sites. They combine their expertise in immuno-oncology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel cancer treatments. This position is based at AbbVie’s new South San Francisco, CA location.

The In Vivo Pharmacology Department is searching for a Senior Scientist with experience in in vitro and in vivo pharmacology study execution and data analysis. This person will support the execution and strategy (including tumor model selection and study designs) of in vivo studies in support of small molecule oncology therapeutic program(s).   The person will be responsible for hands-on laboratory and vivarium work, including efficacy, PK, PK/PD, and tumor model development studies.  As a growth opportunity, the senior scientist will train towards independence as a representative member on project teams and learn biology and other aspects necessary for drug discovery and development. The scientist will collaborate with various cross-functional areas, such as, in vitro biology, translational/biomarkers, toxicology, clinical research, and medicinal chemistry teams. The ideal candidate will be highly motivated, work independently, collaborative with multi-disciplinary teams and have extensive skills in the field of oncology.


  • Initiates, implements, plans, direct hands-on, and executes in vitro (plus) and in vivo (required) cancer research studies
  • May perform pharmacodynamic (PD) assays, using state-of-the-art tools (e.g.: multicolor flow cytometry, FACS, RNAseq, WES) to access oncology target identification, validation, and modulation levels
  • Strategize, design, and analyze data from in vivo studies testing novel therapeutics in various cancer models, such as CDX, PDX, syngeneic models, etc.
  • Demonstrates a high level of initiative in troubleshooting experiments and performing data analysis
  • Effectively collaborates across all intra and cross functional teams
  • Present research findings to project teams and governance bodies and prepare technical reports
  • May coordinate in vivo studies or other collaborative work with external academic, biotechnology, and contract research organizations

  • Ph.D. degree with 0 – 3 years post-doc or pharmaceutical experience
  • Possess theoretical and practical understanding of mouse oncology models, including CDX (required) and PDX models (a plus)
  • Excellent laboratory, record keeping, data analysis and critical thinking skills
  • Independently to plan, execute, and troubleshoot experiments
  • Strong organizational skills, attention to detail, and time-management skills enabling efficiency and independence
  • Ability to manage multiple responsibilities and meet deadlines in a fast-paced environment
  • Strong written and verbal communication skills
  • Scientific leadership abilities and collaborative personality
  • Willing to have schedule flexibility

    Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

    AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.


    AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

    Stock Symbol: ABBV

    Stock Exchange: NYSE

    Company info
    1 North Waukegan Road
    North Chicago

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