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Scientist II/Sr. Scientist I, Neurotoxin & Biologics Process Sciences

Irvine, California
Start date
May 3, 2023

Job Details

AbbVie is recruiting for a Scientist II/Sr. Scientist I, Downstream Process Development position in the Department of Neurotoxin & Biologics Process Sciences (NBPS), at its Irvine, CA site.

Position Description:

The Scientist II/Sr. Scientist I, Downstream Process Development will be an instrumental team member of the NBPS group. The primary roles of this position are to execute/lead all aspects of protein purification, process development, process characterization, process scale-up studies, and pre-formulation studies for natural and recombinant proteins (including neurotoxins) from bacterial cultures during early discovery, process development, and manufacturing support.

This hands-on position is responsible for executing/designing all aspects of protein purification and pre-formulation studies such as high-through-put screening, process development, process and protein characterization, process scale-up/down, and providing technical support for cGMP manufacturing, quality, and regulatory activities. In particular, the candidate is responsible for independently plan, design, and executes the experiments and develops processes to support the purification of natural and recombinant proteins from bacterial cell cultures at small and intermediate scale during various stages of development.

The Scientist II/Sr. Scientist I candidate is expected to possess a clear understanding and in-depth knowledge and experience including but not limited to: chromatography processes, resins screening via high-through put liquid handling system, ultrafiltration/diafiltration, process characterization and optimization, process scale up, scale down model qualifications and validation. The ability to demonstrate a significant level of hands-on experience in several of these areas is expected. Additional responsibilities include data analysis, troubleshooting process and equipment, participation in project teams, lab inventory and organization, maintaining detailed records of batches and experiments. 

This position also requires a desire and ability to work as an integral part of a team and supporting drug discovery teams as well as demonstrate a high degree of flexibility, creativity, and initiative applied to the various duties and aspects of position.

 Furthermore, the position requires the individual to work with and in areas requiring select agents and Toxins access (i.e. Biosafety level 2 and biosafety level 3 laboratories). Access to and use of select agents is regulated by federal policies. Therefore, the candidate must conduct all work activities in compliance with AbbVie internal and applicable regulatory requirements.  AbbVie internal requirements include compliance with ethics, environmental health and safety, financial, human resources, and general business policies, requirements and objectives.


  •         The position requires a MS level education preferably in protein chemistry, biophysics, or biological sciences with 5 - 8 years of relevant research or industrial experience, or B.S. with 7+ years of relevant research or industrial experience. 
  •          Experiences in protein purification technology, process and protein characterization, biochemical and biophysical techniques, as well as statistical experiment design/data analysis skills are highly desired.
  •           Proficiency in purification equipment (such as AKTA systems), computer operations, and some understanding of GMP regulations are required.
  •          Experience in developing novel manufacturing technologies is highly desirable
  • Can hire at Scientist II level or Senior Scientist I level depending on experience


Other qualifications: Proven ability to work independently as well as in a team environment, multitask and ensure flexibility in a dynamic environment required. Excellent oral and written communication skills required as is experience with documentation of experimental plans, analyzing data and generating high quality technical reports. The successful candidate is required to consistently deliver on commitments and respond to internal or external customers' needs in a timely and courteous manner. Motivated to work in a team environment and an awareness to drive continuous improvements required. This position is located in Irvine, CA and may require <5% travel.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off. (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees  

This job is eligible to participate in our short-term incentive programs. 


Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.


AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at Follow @abbvie on Twitter, Facebook, Instagram, and YouTube.

Stock Symbol: ABBV

Stock Exchange: NYSE

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