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Associate Director/Director, Quantitative System Pharmacologist - Cell Therapies

Boston, Massachusetts
Start date
May 3, 2023

Job Details

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Job Description

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Join Takeda as Associate Director/Director, Quantitative System Pharmacologist, Cell Therapies where you will support globaloncology cell therapy research anddevelopment.

How you will contribute:

  • You will joinCellTherapiesClinical Pharmacology & Modelingdepartmentof Takeda Pharmaceuticals in Cambridge MA as a quantitativesystemspharmacology(QSP)lead to support globaloncology cell therapy research anddevelopment.

  • Your primary roleis to developand implementQSPmodelsofnovelcell therapies, specifically theirinteractions withtumor cellsandthe patient’s immune system. If you are interested, the position can also be a hybrid ClinPharm and Modeling role providing both strategic and quantitative leadership.

  • You will collaborate with preclinical, translational medicine, clinical pharmacology and clinical researchto develop mathematical models to understand targeted biological pathways andintracellular interactionsof novel therapeuticmodalities.

  • You will beresponsibleforframing critical questionsto establishthe right modeling & simulation strategiesthatenablelead optimization,identifyPK/PDrelationships, inform dose selection and Go/No Go decisionsbyutilizingmechanisticcellularpharmacology models. Essential qualifications include in-depth understanding ofcell biology─particularly in immunologyand oncology─and numerical methods, as well as hands-on experience with modeling software, ability to clearly present modeling and simulation findings, anddemonstrate ability to thriveina matrix environmentworking attheleadingedge of technologies–there is no owner’s manual for cell therapies!

  • You will report to Head of Cell Therapy Clinical Pharmacology & Modeling. All efforts will be directed toward progression of cell therapies into and through clinical development with the ultimateobjective of global regulatory approval.

  • Develop multi-scale quantitative systems pharmacology models to address project questions and provide scenarios to the project team to guide decision making e.g. influence combination strategies, optimize dose and schedules, biomarker identification and efficacy/toxicity predictions.

  • Conduct extensive literature review to identify suitable mechanistic elements, interactions, rate constants and sub-modules for incorporation into systems (disease) models

  • Identify areas and questions where advanced modeling may add value and work with collaborators to ensure right approach and tools are used.

  • Partner with key stakeholders in discovery, translational medicine, clinical development and clinical pharmacology to facilitate model development and application.

  • Stay abreast with emerging literature and science in the systems biology/pharmacology modeling and simulation sciences.

  • Build and maintain a personal track record of publication in the area of QSP.

  • Participate in writing publications and making scientific presentations consistent with development strategies and publication plan

Minimum Requirements/Qualifications:
  • Ph.D/Pharm.D/M.D with training in chemical or biomedical engineering, immunology, pharmaceutical sciences, mathematics, statistics, or equivalent area

  • Atleast 5-10 years of industry and academic experience in mathematical modeling of biological systems. Job title is flexible based on experience.

  • Strong competency in coding and running modeling and simulation related software such as Matlab, MONOLIX and R is required.

  • Publication(s) applying modeling and simulation approaches to oncology, immunology, cell biology and cancer biology is preferred.

  • Proficiency with systems modeling approaches such as ordinary and/or stochastic differential equations, boolean, agent-based, or other advanced mechanistic modeling approaches is essential.

  • Good understanding of cell biology, physiology, and key concepts in pharmacometrics

  • Strong written, verbal and interpersonal communication skills. Desire to work within a team environment.

  • The candidate should have excellent written and verbal communication, organizational and interpersonal skills, be a strong team player and fully at ease in a matrix environment.

  • Ability to prioritize and manage multiple projects while meeting project deadlines.

What Takeda can offer you:
  • Comprehensive Healthcare: Medical, Dental, and Vision

  • Financial Planning & Stability: 401(k) with company match and Annual Retirement Contribution Plan

  • Health & Wellness programs including onsite flu shots and health screenings

  • Generous time off for vacation and the option to purchase additional vacation days

  • Community Outreach Programs and company match of charitable contributions

  • Family Planning Support

  • Flexible Work Paths

  • Tuition reimbursement

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.

Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.

This position is currently classified as "hybrid" in accordance with Takeda's Hybrid and Remote Work policy.

Base Salary Range: $143,500.00 to $205,000.00, based on candidate professional experience level. Employees may also be eligible for Short-term and Long-Term Incentive benefits as well. Employees are eligible to participate in Medical, Dental, Vision, Life Insurance, 401(k), Charitable Contribution Match, Holidays, Personal Days & Vacation, Tuition Reimbursement Program and Paid Volunteer Time Off. This posting is made in compliance with Colorado's Equal Pay for Equal Work Act, C.R.S. § 8-5-101 et seq


EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


Boston, MA

Worker Type


Worker Sub-Type


Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

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Stock Symbol: TAK

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