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Associate Director, Immunogenicity and Ligand Binding Assays

Employer
Moderna, Inc.
Location
Cambridge, MA
Start date
Mar 31, 2023

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Job Details

The Role:

Moderna is seeking an experienced Bioanalytical senior scientist to join the Bioanalytical and molecular team to support regulated non-clinical studies and clinical trials. A successful incumbent would help integrate basic science research, and bioanalysis, to support drug development for Modernas pipeline.

Heres What Youll Do:

  • Responsible for the design and execution of phase-appropriate clinical bioanalytical strategies including quantitation of therapeutic proteins, immunogenicity (anti- drug antibodies and neutralizing antibody assays) and PK/PD assay method development, validation and sample testing under GLP/GcLP regulations.

  • Responsible to lead the group of scientists to ensure assays are developed in a timely manner to meet program timelines, the qualification or validation of assays is as per regulatory compliance for its intended purpose, and troubleshoot any issues that arise internally or with external CRO partners

  • Responsible for the development of cell based Nab assays and PD assays using ELISA, MSD, Gyros, multiplex LBAs, Luminex based protein assays, immunoblotting and other relevant technologies

  • Support establishing internal GLP bioanalytical capability and facilitate method development to support Modernas portfolio.

  • Responsibilities also include analytical equipment procurement/qualifications, preparation and maintenance of SOPs, determination, and control of critical reagents for example.

  • Collaborate with preclinical and clinical operations and sample management to define sample journey and develop appropriate laboratory manuals.

Heres What Youll Bring to the Table:

  • A Ph.D. in infectious disease, Immuno-oncology, Immunology, Cancer Biology, or related fields and a minimum of 10+ years of industry biotech/pharmaceutical experience. M.S. with extensive bioanalytical experience is considered

  • Experience with RNA, biologics and cell therapy preferred

  • Expert knowledge of various ligand bind binding assay platforms such as ECL, Gyrolabs, cell based assays and other methodologies for pre-clinical and clinical assays is preferred

  • Ability to effectively communicate scientific concepts, program objectives, data analysis within a matrix environment.

  • Knowledge of GLP requirements and understanding of current industry trends and regulatory expectations associated with bioanalytical science.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary year-end shutdown
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

#LI-AM1

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Company

Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.

 

Stock Symbol:

MRNA  

Stock Exchange:

USNASDAQ GS

 

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Find Us
Website
Phone
617-714-6500
Location
200 Technology Square
Cambridge, MA
US

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