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Senior Director, Head of Cancer Biology Tumor Microenvironment Thematic Research Center

Bristol Myers Squibb Company
Redwood City, California
Start date
Mar 29, 2023

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Science/R&D, Biology, Immunology, Oncology
Required Education
Bachelors Degree
Position Type
Full time
Biotech Bay, Best Places to Work

Job Details

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies and transforming response and durability rates for cancer patients. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

Position Summary:

We are seeking a motivated and scientifically exceptional Senior Director to join and provide the strategic vision for our Cancer Biology portfolio. Reporting to the Vice President of TME TRC Biology, the incumbent will provide scientific, business, and strategic vision and leadership for the Cancer Biology Group within the TME TRC.

Position Responsibilities:

In the role as a Senior Director, Head of Cancer Biology within the TME TRC, the ideal candidate will:

  • Provide scientific, business, and strategic vision and leadership for the Cancer Biology Group within the TME TRC.

  • Lead a team of ~25 scientists and effectively collaborate with Lymphoid, Myeloid and Stromal Biology Group Leaders to develop and execute on an integrated TME TRC strategy.

  • Be responsible for executing on the cancer biology portfolio, with an emphasis on small molecule drug discovery.

  • Guide and ensure the transition of innovative targets from hit discovery/lead optimization through to human proof-of-mechanism (PoM) and proof-of-concept (PoC) evaluation.

  • Require close collaboration with cross-functional teams, including Lead Development & Optimization, Small Molecule Drug Development, In Vivo Pharmacology, Translational, Bioinformatics, Clinical, Commercial and Early Development Project Leads to inform patient segmentation and biomarker opportunities associated with an initial clinical development plan (CDP).

  • As a subject-matter expert, contribute to the scientific assessment of external opportunities in collaboration with business development (BD) and Integrative Sciences teams, including asset level diligence and the evaluation of novel technologies or platforms that complement our drug discovery and translational capabilities.

Experience =

Basic Qualifications:

  • Bachelor’s Degree

    • 15+ years of academic and / or industry experience


  • Master’s Degree

    • 12+ years of academic and / or industry experience


  • Ph.D. or equivalent advanced degree in the Life Sciences

    • 10+ years of academic and / or industry experience

    • 8+ years of leadership experience

Preferred Qualifications:

  • Ph.D. (or equivalent) in Cancer-Cell Biology (or related discipline) with a strong understanding of cancer-intrinsic mechanisms shaping the TME, and a minimum of 12 years of relevant industry experience in oncology drug discovery and drug development with emphasis in small molecule R&ED

  • Proven track record in personally leading and managing teams to advance programs (particularly small molecules) from research through to early development

  • Decisive leader with a proven track record in fast-paced environments, with a passion for innovation, collaboration, and teamwork and ability to successfully execute and progress programs in a matrixed environment

  • Exceptional interpersonal and communication skills, including high emotional intelligence (EQ) with strong leadership skills

  • Outstanding decision making, organizational, and analytical skills

  • Strong understanding of relevant regulatory health authority expectations and regulations for drug development, with a focus on early development but with an understanding of implications toward full development

  • Working knowledge of all functional areas of exploratory development, including biology, chemistry, biologics, toxicology, CMC, translational medicine, early clinical development with strong understanding of small molecule PK/PD/efficacy studies required to support decision-making

  • Ability to effectively multi-task across exploratory discovery and development assets

  • Demonstrated ability to objectively assess complex but relatively sparse data sets, make informed decisions and act in the face of uncertainty

  • Proven track-record successfully managing, leading, developing and retaining high performing, cross-functional matrix teams (Ph.D and non-Ph.D.)

  • Acts as a credible, influential, and respected spokesperson for TME TRC research and early development – internally and externally

  • Willingness to take educated risks in moving the business needs forward

  • Willing to break traditions, test boundaries and challenge status quo

The starting compensation for this job is a range from $231,105.00 - $290,131.00, plus incentive cash and stock opportunities (based on eligibility).

The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience.

For more on benefits, please visit our BMS Careers site.

Eligibility for specific benefits listed in our careers site may vary based on the job and location.




If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol
Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.

COVID-19 Information
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation.Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment.This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.


Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

At Bristol Myers Squibb, we believe in the power of science to address some of the most challenging diseases of our time. Our focus on these unmet needs comes during a remarkable time, when unprecedented scientific breakthroughs are advancing the treatment of disease as never before in human history.

We work every day to transform patients’ lives through science. Each day, our employees around the world work together for patients – they are at the center of everything we do. They inspire us. They are the reason we come to work each day.

We combine the agility of a biotech with the reach and resources of an established pharmaceutical company to create a global leading biopharma company powered by talented individuals who drive scientific innovation.

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