Contract, Research Associate Functional Genomics

About Maze Therapeutics

Maze is a clinical-stage biopharmaceutical company harnessing the power of human genetics to transform the lives of patients through the development of a pipeline of novel precision medicines for patients with genetically defined diseases. Maze is leveraging Compass™, a proprietary, end-to-end purpose built platform to advance a pipeline of precision medicines across four disease areas - renal, cardiac, neurological and metabolic diseases. Our flexible business model aims to translate our genetic insights into new therapies for patients as possible.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients. 

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.  

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others. 

Stand True – Our integrity is foundational; it guides us no matter the obstacle. 

Role Description:

• Design, optimize, and execute cellular assays to enable high throughput functional genomics screening aimed at identifying novel genetic modifier targets
• Engineer cell models in disease-relevant systems for hit validation
• Perform mechanism of action studies, including analysis of protein levels, gene expression, and pathway activity to validate and advance targets
• Collaborate closely with colleagues on our therapeutic area teams to develop assay strategies for primary screens and secondary assays
• Independently summarize, analyze, and regularly present work internally and externally
• Contribute to development of automated processes, data analysis methods, and advanced assay technologies

Qualifications:

• BS/MS in a Biology related field and at least 2 years of relevant experience working on an independent project
• Expertise in mammalian cell culture is required; experience with genetic perturbation of mammalian cells (CRISPR, RNAi, ASO, lentiviral cell engineering, etc.) is strongly preferred
• Broad laboratory experience and skills in molecular and cell biology (DNA/RNA extraction, PCR/qPCR, Flow Cytometry, NGS library prep, etc.)
• Expertise in cell-based assay development using a variety of readout technologies such as luciferase, ELISA/immuno-assays, and qPCR/ddPCR gene expression-based assays
• Experience with arrayed screening and comfort with laboratory automation is preferred
• Familiarity with microscopy and image analysis is a plus
• Strong experimental design, troubleshooting, and data analysis skills
• Excellent communication, presentation, collaboration, and organizational skills to work as part of a team
• Proven ability to think critically, adapt to new data, multi-task, and work in a fast-paced environment

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of compensation will depend upon a variety of job-related factors, which may include professional experience, skills and job location. The expected salary range for this role may be modified in the future.