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Scientist

Employer
4D Molecular Therapeutics
Location
Emeryville, California
Start date
Mar 28, 2023

View more

Discipline
Science/R&D, Biotechnology
Required Education
Bachelors Degree
Position Type
Full time
Hotbed
Biotech Bay, Best Places to Work

Job Details

4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage genetic medicines company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of genetic medicines using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted genetic medicine products. The company is initially focused in three therapeutic areas: ophthalmology, pulmonology, and cardiology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT has five active clinical product candidates: 4D-150 is in Phase 1/2 clinical trials for Wet AMD and DME, 4D-710 is in Phase 1/2 clinical trials for Cystic Fibrosis lung disease, 4D-310 is in a Phase 1/2 clinical trial for Fabry disease, 4D-125 is in a Phase 1/2 clinical trial for XLRP, and 4D-110 is in a Phase 1 clinical trial for Choroideremia. In addition, 4DMT has two preclinical products: 4D-175 for geographic atrophy and 4D-725 for AATLD.

  4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA. 

GENERAL SUMMARY:  

The Scientist position in Biomarkers group will focus on molecular biology assays including method development and sample testing.  This entails learning existing methods, method & equipment optimization/troubleshooting as well as testing valuable clinical and non-clinical samples.  The data generated by the new hire will inform biodistribution and PK in our clinical and non-clinical programs as well as determine the success of new vector products. This new scientist will also become the lead for our growing biobank effort and integration into advanced sample/data management software and associated tasks.  The new hire will be expected to integrate into department and cross functional project teams as a molecular biology subject matter expert.  The new scientist will be also expected to cross-train with other members of biomarkers team and 4D to share expertise and pick up new scientific techniques.  

% RESPONSIBILTIES:  

  • Design/Optimize/Perform molecular biology experiments: 50%  
  • Lead biobank effort: 40%  
  • Meetings, planning and administrative tasks: 10% 

PRIMARY RESPONSIBILITIES: 

  • Support in-house method development and sample testing for DNA/RNA-based molecular biology assays to support exploratory clinical and non-clinical studies  
  • Lead 4D biobank effort/project: design and integration of bio-sample library into sample management software, inventory management and sample receiving/distribution   
  • Attend and contribute to meetings with external CROs, departmental meetings, cross functional and clinical team meetings  
  • Identify and implement innovative technologies to improve 4D biomarker strategy  
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time 

QUALIFICATIONS: 

Education & Experince: 

  • Ph.D. in related scientific discipline and 2+ years industry experience or MS/BS in related scientific discipline, and 4+ years industry experience  

Skills: 

  • Proven expertise in ddPCR or qPCR, as well as other nucleic acid-based assays 
  • Prior experience in assay development or drug discovery is a plus 
  • Experience working with biospecimens (tissue, blood) is nice to have 
  • Excellent organizational capabilities and ability to work independently (with appropriate supervision)  
  • Strong analytical skills and attention to detail 

Physical Requirements of the role: 

  • The candidate will be expected to be onsite for lab work 4-5 days per week as well as: 
  • Adhere to PPE requirements and complete all required safety training  
  • Adhere to 4DMT Covid protocols and policy 

Base salary compensation range: 

Minimum 

Maximum 

$125,000/year 

$142,000/year 

 

Please note, the base salary compensation range and actual salary offered to the final candidate is dependent on variety of factors: candidate’s geographical location, relevant work experience, skills, and years of experience. 

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran, and any other category protected under applicable federal, state, provincial and local laws.   Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

Company

4DMT is a gene therapy company with a transformative discovery platform --Therapeutic Vector Evolution --that enables our “disease first” approach to product discovery and development, thereby allowing us to customize our AAV vectors to target specific tissue types associated with the underlying disease.


At 4DMT we are creating and developing optimized “biopharmaceutical grade” AAV vectors that will allow us uniquely to unlock the full potential of gene therapy. Our customized and proprietary AAV vectors are each designed, according to a 4DMT Target Vector Profile, to deliver genes to specific cells and tissues in the body to eradicate both rare and large market diseases.


While AAV gene therapy pioneers are making great strides with the first wave of products, hurdles still exist with the use of conventional vectors. The most commonly used AAV capsids (e.g., AAV2, 5, 8 and 9) were identified either 1) as contaminants in lab stocks of adenovirus, or 2) through monkey tissue processing. Therefore, these conventional vectors are not targeted specifically to any tissue in the body. This can lead to inefficient and non-specific delivery, thus requiring extremely high doses and potentially resulting in toxicities (including inflammation), high manufacturing burdens and suboptimal efficacy. In addition, suboptimal routes of delivery can be required for delivery to the right tissues (e.g., subretinal delivery to the retina). Finally, pre-existing neutralizing antibodies in many patients can limit efficacy, clinical trial enrollment and market sizes. 4DMT Innovation empowers us to create new and improved next generation AAV capsids to allow targeted delivery of our products by the optimal clinical route of administration.


At 4DMT we use our robust discovery platform, termed “Therapeutic Vector Evolution,” to create customized and proprietary gene delivery vehicles (novel AAV vectors) to deliver genes to specific tissues and cells in the body by the optimal route of administration. We use the power of evolution to create and refine these optimized vectors through genetic diversification and then natural selection in vivo.


4D Purpose Statement:  Boldly Innovating to Unlock the Full Potential of Gene Therapy for Countless Patients


GUIDING PRINCIPLES

 

  • Dare to Cure - Patients are waiting. Create big dreams for patients and take calculated risks to achieve them
  • Break Boundaries - Question the status quo and innovate beyond conventional approaches
  • Beyond Yourself - It's about patients, their families, our team, our families. We strengthen each other.
  • Prepare and Execute Relentlessly - Start with the end in mind, over-prepare and make contingency plans to your contingency plans


We invite all of you who share our passion and vision in creating the ultimate gene therapy products to cure genetic and rare diseases in children and adults. We seek the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers generous benefits and provides challenging opportunities for career development. 
 

Company info
Website
Phone
510-505-2680
Location
5858 Horton St. Suite 455
Emeryville
California
94608
United States

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