Bioinformatics Analyst I

Bioinformatics Analyst I

Job ID: req3323
Employee Type: exempt full-time
Division: Cancer Research Technology Program
Facility: Frederick: ATRF
Location: 8560 Progress Dr, Frederick, MD 21701 USA

The Frederick National Laboratory is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI) and operated by Leidos Biomedical Research, Inc.  The lab addresses some of the most urgent and intractable problems in the biomedical sciences in cancer and AIDS, drug development and first-in-human clinical trials, applications of nanotechnology in medicine, and rapid response to emerging threats of infectious diseases.

Accountability, Compassion, Collaboration, Dedication, Integrity and Versatility; it's the FNL way.

PROGRAM DESCRIPTION         

The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community and provides dedicated support to NCI's intramural Center for Cancer Research (CCR). The dedicated units provide expertise in electron microscopy, protein characterization, mass spectrometry, protein expression, optical microscopy, and genomics. These research efforts are an integral part of CCR at the Frederick National Laboratory for Cancer Research (FNLCR), where CRTP scientists work collaboratively with intramural NCI investigators to provide research technologies and expertise.

The Genomics Technology Laboratory (GTL) of CRTP is a CCR dedicated genomics core facility.  We have an exceptional team of molecular biologist, genomicist, and bioinformatics. We develop cutting edge genomics applications based on NGS and non-NGS technologies and provide these technologies as core services to the broad CCR community.  Examples of the applications include Whole Exome sequencing, targeted sequencing, CRISPR cas9 library screening, Global or Targeted DNA methylation, TCR/BCR sequencing, HIV integration site sequencing, cell free DNA/RNA based biomarker assays.  Bioinformatics tools and pipelines are integral part of the applications.  

KEY ROLES/RESPONSIBILITIES

• Provide collaborative bioinformatics support to the CCR Genomics Technology Laboratory (GTL). It is anticipated that support will be required in ATRF to work directly with CCR GTL staff on project data analysis to support NGS data generation, alignments to reference genomes, data quality control and further downstream analysis
• Develop, manage and maintain data management pipelines for NGS data generated for GTL
• Attend lab meetings; collect and review data; analyze and interpret data and results; provide reports based on analysis of scientific data, and reporting research outcomes to make recommendations for future work
• Work with staff on data visualization to support the preparation of presentations and manuscripts for submission to scientific journals
• Work in conjunction with the ABCS Sequencing Facility Bioinformatics team at Frederick National Laboratory to adopt best practices for analysis of various NGS data
• Liaison between the GTL and IT to resolve network and other IT issues pertaining to the operational integrity of the program’s software and hardware

BASIC QUALIFICATIONS

To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:

• Possession of a Bachelor's degree in biomedical science/bioinformatics/math/computer related field from an accredited college/university according to the Council for Higher Education Accreditation (CHEA). Foreign degrees must be evaluated for U.S. equivalency
• Ability to obtain and maintain a security clearance

PREFERRED QUALIFICATIONS 

Candidates with these desired skills will be given preferential consideration:

• Experience in a biological research laboratory environment with a strong background in bioinformatics application development
• Experience in genomic and sequence analysis such as RNA-seq, Exome-seq, Chip-seq and metagenomics analysis, construction of data processing pipelines, and quality control/quality assurance analysis
• Strong computational/bioinformatics skills and demonstrated ability to work with scientists to deliver on objectives in defined timelines are required
• Possession of a Master’s degree (PhD degree preferred)
• Experience in NGS sequencing technology and molecular biology
• Experience in single-cell genomic and transcriptomic sequencing technologies and data analyses
• Experience in data integration and application development
• Knowledge of cancer biology
• Familiarity with publicly available data sources such as ENCODE, Ensembl, NCBI, TCGA, cBioPortal, Broad FireHose
• Knowledge of working in a cluster environment
• Experience with Snakemake, make, or other workflow management systems
• Commitment to solving biological problems and communicating these solutions. Proven success in independent efforts and delivering high quality data with biological relevance to customers

Equal Opportunity Employer (EOE) | Minority/Female/Disabled/Veteran (M/F/D/V) | Drug Free Workplace (DFW)

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