Principal Scientist I/II - Non-Viral Delivery

OPPORTUNITY
Mammoth Biosciences is hiring for a Principal Scientist I/II, Non-Viral Delivery. In this role the ideal candidate will be responsible for leading the lipid nanoparticle (LNP) formulation discovery and scale up activities for non-viral delivery technologies at Mammoth. The candidate will be responsible for the screening of various lipids and formulation/process parameters for the lead optimization for delivery of Mammoth’s proprietary CRISPR nucleases. In addition, will be responsible for in-house research-scale production, related process development, and quality control of the test articles to support Mammoth’s ex vivo and in vivo studies. 
KEY RESPONSIBILITIES

• Lead DOE-based LNP formulation screening/discovery campaigns directed toward in vivo and ex vivo delivery of Mammoth’s proprietary CRISPR-based gene editing systems  
• Design, implement and execute early process development activities for LNP scale-up
• Critically review and analyze data, and communicate results and conclusions; present and defend ideas in cross-functional meetings
• Explore and evaluate non-viral delivery technologies for various therapeutics indications
• Explore new orthogonal characterization assays and rigorously QC all the test articles
• Manage the non-viral delivery projects to support deliverables along established timelines
• Train, guide, and manage the researchers on various non-viral delivery activities

REQUIRED QUALIFICATIONS

• Bachelor's degree in related field and 10+ years industry experience (or Master’s degree and 8+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 6+ years of industry experience) (Principal Scientist I) 
• Bachelor's degree in related field and 12+ years industry experience (or Master’s degree and 10+ years experience or Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical engineering, Biomedical Engineering, Statistics or related discipline with 8+ years of industry experience) (Principal Scientist II) 
• Expertise in LNP formulation screening and optimization 
• Expertise in using design of experiment (DOE), relevant statistical softwares (JMP), and predictive analytics for formulation discovery

PREFERRED QUALIFICATIONS

• Exposure to LNP scale-up and process development activities
• Hands-on expertise in various basic analytical and biophysical methods/assays of LNP characterization such as, particularly size, zeta potential, and nucleic acid encapsulation/release, PKa, etc. 
• Foundation in experimental documentation, basic statistical analysis and data presentation 
• Experience working with internal and external research collaborators and CROs
• Highly motivated, hard working, and collaborative spirit

BENEFITS

• Company-paid health/vision/dental benefits
• Unlimited vacation and generous sick time
• Company-sponsored meals and snacks
• Wellness, caregiver, and ergonomics benefits
• 401(k) with company matching

Base Salary Range: $118,750 - $215,250

The listed base salary range is for Mammoth employees in the Bay Area. Actual base salary will be determined by geographic work location, relevant professional experience, applicable skills, and internal equity. The base salary range for those working remotely outside of the San Francisco Bay Area may differ and will be determined by industry market data for the role and specific region.

Mammoth Biosciences is a biotechnology company focused on leveraging its proprietary ultracompact CRISPR systems to develop long-term curative therapies, as well as other applications such as decentralized precision diagnostics. Founded by CRISPR pioneer and Nobel laureate Jennifer Doudna and Trevor Martin, Janice Chen, and Lucas Harrington, the company’s ultracompact proteins are designed to enable in vivo gene editing in difficult to reach tissues utilizing both nuclease applications and new editing modalities beyond double stranded breaks, including base editing, gene writing, and epigenetic editing. The company is building out its pipeline of potential in vivo gene editing therapeutics and capabilities and has partnerships with leading pharmaceutical and biotechnology companies to broaden the reach of its innovative and proprietary technology. Mammoth’s deep science and industry experience, along with a robust and differentiated intellectual property portfolio, have enabled the company to further its mission to transform the lives of patients and deliver on the full promise of CRISPR technologies.

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth, and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.

Mammoth Biosciences requires that all employees be vaccinated against Covid-19 as a condition of at-will employment, with exceptions for medical or religious reasons in compliance with local, state, and federal law.