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Associate Scientist I, Protein Process Development & Manufacturing

Employer
Vaxcyte, Inc.
Location
San Carlos, California
Start date
Mar 25, 2023

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Job Details

Company Profile:

Vaxcyte, Inc. (Nasdaq: PCVX) is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum pneumococcal conjugate vaccine being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits. Vaxcyte’s pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of greater than 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit www.vaxcyte.com.
 
Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 100 employees and anticipates continued, significant growth. On January 6, 2022, Vaxcyte announced that the U.S. Food and Drug Administration (FDA) had cleared the Investigational New Drug (IND) application for VAX-24, its lead vaccine candidate. The Company initiated the VAX-24 Phase 1/2 clinical proof-of-concept study in adults in the first quarter of 2022 and expects to announce Phase 2 topline immunogenicity, safety, and tolerability results by the end of the year. VAX-24 was designed to prevent IPD, which can be most serious for infants, young children, older adults and those with immune deficiencies or certain chronic health conditions. Given the global impact of pneumococcal disease remains significant, the public health community continues to advocate for vaccines that can offer broader protection to prevent IPD. Vaxcyte’s PCV franchise, consisting of VAX-24 and VAX-XP, is designed specifically to address this need and has the potential to deliver the broadest protection for this very serious disease.
 
Summary:
 
Vaxcyte is looking for a motivated and collaborative individual to join the protein process development team.  This is an entry level position, that can lead to a highly impactful career within Vaxcyte.  By managing general lab work, generating needed materials for development use, and running assays that generate highly valuable data on process performance, this person can make a significant impact on the development of life-saving vaccines.  As a member of the protein development team, this individual will have the opportunity to learn cutting edge technology using cell-free protein expression and Nobel Prize-winning click chemistry. The successful candidate will have the following skills and qualities:
 
·A friendly and highly collaborative team player, that fosters a positive and productive work environment.
·A diligent research associate, who enjoys being in the lab.
·A confident individual who speaks up, is open to input, and remains focused on achieving the best results to achieve company goals.
The ability to analyze data, draw conclusions, and communicate results to scientific peers.
·A strong sense of ownership and accountability; commitment to Vaxcyte’s mission.
Essential Functions:
    • Preparation of buffers, and general lab assistance.
    • Execution of chromatography, depth filtration, tangential flow filtration, and normal flow filtration experiments, as well as analyzing the data.
    • Keep process records that facilitate interpretation and retrievability of data generated.
    • Presentation of data to peer groups.
    • Support scale up activities for processes as part of technology transfer to CMOs.
    • Run in-process tests and product quality assays.

Requirements:
    • BS in Chemical Engineering, Biochemistry, or a related discipline with 0-2 years of industry experience.
    • Strong interpersonal skills, with good written and verbal communication skills.
    • Basic proteinpurificationknowledgeand/orexperience with lab work.
    • Proficiency running analytical methods is a plus; including SDS-PAGE, Endosafe, UV spectroscopy, and HPLC.
    • Familiarity with AKTA pilot chromatography systems and UNICORN software is a plus.
    • Experience operating tangential flow filtration systems; single-pass TFF is a plus.
    • Experience working with an ELN (Benchling) is a plus.
    • Experience with GMP/GLP systems is a plus.
    • This position is an on-site position.
    • All Vaxcyte employees require vaccination against COVID-19.

Reports to: Staff Scientist, Protein Process Development and Manufacturing
 
Location: San Carlos, CA
 
Compensation:
The compensation package will be competitive and includes comprehensive benefits and an equity component.
 
Salary Range: $71,000 - $84,000
 
 

Company

Vaxcyte, Inc. (Nasdaq: PCVX) is a next-generation vaccine company seeking to improve global health by developing superior and novel vaccines designed to prevent some of the most common and deadly infectious diseases worldwide. Our exclusively licensed cell-free protein synthesis platform and our proprietary know how enable us to design and produce optimized protein carriers and antigens, the critical building blocks of vaccines, in ways that we believe conventional vaccine technologies cannot. Our lead vaccine candidate, VAX-24, is a preclinical, 24-valent broad-spectrum pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease. Our pipeline also includes VAX-XP, a PCV with an expanded breadth of coverage of at least 30 strains; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; and VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease by targeting the keystone pathogen responsible for this chronic, oral inflammatory disease.

Company info
Website
Phone
(650) 837-0111
Location
825 Industrial Road, Suite 300
San Carlos
CA
94070
US

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