Principal Scientist I, Precision Medicine Oncology

POSITION DESCRIPTION:

The Precision Medicine Translational Oncology group is committed to drive translational and biomarker efforts for our pre-clinical and clinical stage programs.  We are seeking a highly motivated scientist with a passion for translational oncology, and a proven track record of accomplishments as a biomarker scientist, who enjoys working in a fast-paced and dynamic environment.  The successful candidate is expected to conceive and execute biomarker strategies for clinical stage assets.

 

KEY GOALS INCLUDE:

• Lead design and implementation of biomarker strategies for one or more clinical trials and serve as point of contact for all aspects of clinical biomarker strategy providing scientific expertise and leadership as a member of a cross-functional project team.
• Identify pharmacodynamic biomarkers, tumor indications, patient sensitivity biomarkers, and mechanism-based drug combinations for AbbVie Oncology pipeline
• Articulate hypotheses, workplans, and effectively present results to a variety of audiences in both oral and written communications
• Ensure timely biomarker assay development, fit for purpose validation and outsourcing on various platforms such as IHC, qPCR/NGS, ligand binding assay, proteomic/genomic profiling, and flow cytometry
• Leads identification and selection of Clinical Biomarker vendors, write SOWs, drive projects to completion and manages vendor relationship
• Leadership of biomarker subteams to enable cross functional collaboration on biomarker implementation
• Author biomarker sections of protocols, ICFs, IRB responses, regulatory documents, and others
• Critically evaluate relevant scientific and regulatory advancements and integrate into research programs.

QUALIFICATIONS:

•     Bachelor’s Degree or equivalent education and typically 14 years of experience, Master’s Degree or equivalent education and typically 12 years of biopharmaceutical industry experience, PhD and typically 6 years of biopharmaceutical experience (an equivalent combination of experience and education may be considered).

•     Possess thorough theoretical and practical understanding of own scientific discipline.

•     Effective writer and communicator of research or other regulatory materials.

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Other PREFERRED QUALIFICATIONS:

 

• Strong scientific background in tumor biology and oncology supported by publication record
• Clinical development experience interacting with teams conducting clinical trials
• Demonstrated leadership in translational sciences, employing pharmacodynamic, predictive and exploratory biomarkers
• Experience in analysis of large datasets and knowledge of biostatistics
• Experience in assay development, qualification and implementing biomarker assays on diverse platforms including IHC/IF, gene expression profiling, flow cytometry, and ligand binding assays
• Companion diagnostics development knowledge is a plus
• Effectively work in a cross-functional team environment, interacting with various functions within the organization such as discovery and clinical colleagues as well as vendors/academic sites/KOLs
• Team player who is highly organized and able to manage timeline driven multiple concurrent projects with minimal oversight
• Organization, orientation to details, and effective time management with an ability to adapt to changing priorities
• Excellent written and oral presentation skills in the English language

 

 

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.

We offer a comprehensive package of benefits including paid time off. (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees  

This job is eligible to participate in our short-term incentive programs. 

This job is eligible to participate in our long-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law. 

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.