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Scientist, Analytical Development

Moderna, Inc.
Norwood, MA
Start date
Mar 25, 2023

Job Details

The Role:

Modernas Small molecules and lipids team is seeking a highly skilled and talented Scientist with a strong analytical background in separation sciences and mass spectrometry, with experience in structural characterization. The individual in this role will help support method development, impurity identification, and structure elucidation of small molecule/lipid components of mRNA nanoparticles, drug substance, drug products and raw materials for pre-clinical to late-stage programs. The individual is expected to work in a highly collaborative, cross functional team environment, and interface with Analytical Development, Process Development, Preformulation and Strategy Teams.

This role will be located at the Moderna Technology Center in Norwood, MA.

Heres What Youll Do:

  • Develop, optimize, and execute analytical separations, mass spectrometry, and gas chromatography methods focused on impurity profiling, structural elucidation, forced degradation, and quantification of small molecules and lipids using LC-UV/CAD, and high-resolution LC-MS/MS, and GC-MS/FID.

  • Expand knowledge and research using new analytical techniques to consolidate and optimize methods.

  • Apply advanced techniques, experimental design and statistical data analysis (DryLabs, JMP, SIMCA, etc.) to characterize raw materials, drug substance and drug products.

  • Work closely with colleagues within Moderna Process Chemistry, Process Development, Formulation, Analytical Tech Operations, Analytical Sciences and Technology and QC teams to support raw material testing, process optimization, method development, forced degradation studies, hands-on troubleshooting, and technical investigations.

  • Contribute to scientific and strategy discussions to support Analytical Development programs, initiatives, and investigations.

  • Demonstrate independent judgment in technique and method selection, study design, generate and contribute to data analysis, technical report writing and provide summary presentations to internal and external stake holders.

  • Maintain a safe laboratory work environment and be accountable for good documentation practices.

Heres What Youll Bring to the Table:

  • PhD in Analytical Chemistry or related field with 1-5 years (or MS with 5+ years) of industry experience in analytical development or in the small-molecule biopharmaceutical space.

  • Knowledge and experience in small molecule analytics, including method development, quantification, characterization, and structure elucidation (high-resolution MSn)

  • Strong scientific background in separation techniques and chromatography methods (SPE, RP-IP, HILIC, SEC, CE) including the isolation and identification of low-level impurities.

  • Familiarity working with large MS data sets and statistical evaluation of data (SIMCA, MPP, Dry Labs).

  • Knowledge of nucleic acid chemistry and biology and standard methods of analysis of these molecules.

  • Knowledge of theories, principles and techniques of relevant scientific areas and understanding of industry practices and standards

  • Excellent communication (oral and written) and attention to detail

  • Strong interpersonal skills with an eagerness to work with and support colleagues in other departments

  • Ability to navigate through ambiguity and rapid growth and adapt to change.

  • (Preferred) Knowledge of current FDA and ICH guidelines.

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

  • Highly competitive and inclusive medical, dental and vision coverage options
  • Flexible Spending Accounts for medical expenses and dependent care expenses
  • Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
  • Family care benefits, including subsidized back-up care options and on-demand tutoring
  • Free premium access to fitness, nutrition, and mindfulness classes
  • Exclusive preferred pricing on Peloton fitness equipment
  • Adoption and family-planning benefits
  • Dedicated care coordination support for our LGBTQ+ community
  • Generous paid time off, including:
    Vacation, sick time and holidays
    Volunteer time to participate within your community
    Discretionary year-end shutdown
    Paid sabbatical after 5 years; every 3 years thereafter
  • Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
  • 401k match and Financial Planning tools
  • Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
  • Complimentary concierge service including home services research, travel booking, and entertainment requests
  • Free parking or subsidized commuter passes
  • Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.




Moderna is advancing messenger RNA (mRNA) science to create a new class of transformative medicines for patients. Moderna’s platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, providing the Company the capability to pursue in parallel a robust pipeline of new development candidates. Moderna is developing therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases and cardiovascular diseases, independently and with strategic collaborators.

mRNA is now a turning point in the history of science, medicine, technology, even humankind itself. With this breakthrough discovery, many of the world’s biggest and most challenging medical problems are no longer a question of “how?” but merely a question of “when?”

Come with us as we pursue the uncharted reaches of possibility and make your mark on the future of medicine.


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