Process Development Engineer III, Upstream Development - Gene Therapy

Regeneron's Preclinical Manufacturing and Process Development group (PMPD) is looking for a Process Development Engineer III: Upstream Development – Gene Therapy, responsible for upstream development efforts to support manufacturing process development functions. In this role you will work as part of a multi-functional team to provide Adeno-Associated Virus (AAV) manufacturing processes and products with the aim of providing treatment to unmet medical needs through gene therapy. This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institution knowledge gained from working for a larger firm.

A Typical Day in the Role Might Look Like:

• Design optimized, characterized and robust seed train and bioreactor processes for the upstream production of viral vectors in suspension cell lines suitable for future GMP clinical production.
• Lead the design and optimization of transfection and bioreactor parameters for viral production using multivariate design of experiment approaches.
• Serve as upstream domain expertise and lead technology transfer to clinical manufacturing for future gene therapy programs.
• Contribute to optimization studies for the development of in-house chemically defined medium for viral production through design of experiment approach and omics analysis.
• Conduct technology development studies aimed at enhancing the understanding of or improving viral production process.
• Cross-train on and provide support for analytical and downstream operations.

This Role May Be For You If You Have:

• A Strong Fundamental understanding of the principles of upstream process development.
• History of developing upstream steps within bioprocesses.
• Experience with bioreactor scale up and operations.

This position requires a Ph.D. degree with 0-3+, a MS with 5+years of experience and/or BS’s degree with 7-10+ yrs proven ability in either Chemical Engineering, Biochemical Engineering, Biochemistry, or related field. The extent of the candidate’s prior experience will determine the grade of the position. Meaningful experience with some of the following systems is helpful: NOVA FLEX, AMBR250 bioreactors, Bench top bioreactors, Single-use bioreactors (50-500 L). Knowledge of Biosafety cabinets, incubators, autoclave, Rockwell RSView32, Pi Historian, JMP, LIMS, prior experience with producing AAV-based gene therapies is a plus.

This role will periodically require short duration physical exertions, including light-medium weight lifting.

YouTube Video on PMPD Viral Production Core:

https://www.youtube.com/watch?v=KtR5_mKkXlo&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=1

YouTube Video on Diversity Equity & Inclusion in PMPD:

https://www.youtube.com/watch?v=BEORUD_Fnjk&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=3

YouTube Video on Career Development at Regeneron:

https://www.youtube.com/watch?v=4fg18hC-gsw&list=PL_7lj13Lp4fH4OssUue8J5bby6muZsaR4&index=2

#pmpd

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides comprehensive benefits including health and wellness programs, fitness centers and equity awards, annual bonuses, and paid time off for eligible employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or parental status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.

The salary ranges provided are shown in accordance with U.S. law and apply to U.S. based positions, where the hired candidate will be located in the U.S. If you are outside the U.S, please speak with your recruiter about salaries and benefits in your location.

Salary Range (annually)

$103,600.00 - $169,000.00