Senior Research Associate 2, In Vitro Pharmacology

Eikon Therapeutics is a new biopharmaceutical company employing revolutionary technology at the intersection of chemistry, engineering, computation, and biology to discover novel treatments for life-threatening diseases. Eikon’s discovery platform is built on groundbreaking innovations from its founders (Nobel Prize, 2014), culminating in the creation of microscopes which enable real time, molecular-resolution measurements of protein movement in living cells, thereby unlocking otherwise intractable classes of proteins as drug targets.

Position

This Senior Research Associate 2, In Vitro Pharmacology will be working with the pharmacology team and supporting the analysis of tissues to understand target engagement, potential biomarker and their relationship to efficacy in disease models.  This position requires a person to be highly skilled in numerous molecular biology techniques including the development and execution of immunoassays, PCR techniques for gene expression analysis and genotyping method development, flow cytometry and possibly immuno-histochemical techniques.  An interest and desire to learn high resolution microscopy and single molecule tracking technology would be plus.  The position reports initially to the VP of Pharmacology and interacts with numerous project teams of chemistry, biology and pharmacology scientists.  This is an opportunity to significantly impact Eikon’s drug discovery pipeline and work in a fast-paced and highly energetic environment.

About You

You have a desire to contribute to a face paced, energetic, scientifically driven group.  You are a highly skilled molecular biologist with experience working with whole tissues who is versatile and able to pivot between multiple techniques in a fast-paced environment.  You have great communication skills and are able to describe you data to colleagues, management and project teams.  You’re conscientious and with great attention to detail, documentation and organization are second nature.  You are excited about being a foundational member of a rapidly growing team.

What You’ll Do

• Support the in vivo characterization of novel chemical entities by performing the ex-vivo molecular analysis on tissues from pre-clinical disease models to understand target engagement and resulting efficacy
• Engage with animal scientist colleagues to understand the study design and timelines for studies. Be prepared to analyze tissues from studies as they are available.  Work with numerous molecular techniques to analyze the tissues and report data to pharmacology and project teams
• Develop, optimize, and validate biomarker assays using tool compounds to either building on ideas from research biology or perform novel development
• Work flexibly across numerous drug development programs in various therapeutic areas
• Potentially mentor junior scientists in performing PD assays from tissues to encourage cross-training on techniques. Maintain excellent and timely lab note book entries
• Be a technical leader that can provide feedback on the project team. Some contribution to study reports to be using for regulatory filings

Qualifications

• A minimum of 8+ years working in a molecular biology lab with experience analyzing whole tissues (e.g. serum, tumor, whole organ tissue etc)
• Experience with cell culture, immuno-assay development and optimization (e.g. ELISA and MSD), real time and conventional PCR techniques and flow-cytometry; immune-histo chemistry skills a plus
• Management and/or training of junior scientists possibly, accurate capturing and presentation of results and authoring of selected study reports
• You thrive in team environments, seek opportunities for collaboration and value team members success as much as your own
• Excellent written and oral communication skills; attention to detail and meticulous lab notebook entries

At Eikon, employee compensation also includes bonus and equity compensation, in addition to several generous benefit programs, including:   

• 401k plan with company matching 
• Medical (premiums covered by Eikon at 95%), dental and vision insurance (premiums covered by Eikon at 100%) 
• Mental health and wellness benefits 
• Weeklong summer and winter holiday shutdowns 
• Generous paid time off and holiday policies 
• Life/AD&D Insurance (premiums covered by Eikon at 100%) and optional supplemental employee-paid life/AD&D policies 
• Enhanced parental leave benefit 
• Daily subsidized lunch program when on-site 

The expected salary range for this role is $98,000 to $113,000, depending on skills, competency and the market demand for your expertise.