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Research Associate, Process Chemistry CONTRACT

Entrada Therapeutics
Boston, MA
Start date
Mar 18, 2023

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Job Details

The Organization

What's happening at Entrada Therapeutics? Our mission is to transform the treatment of devastating diseases and improve patients' quality of life using intracellular biologics. Leveraging our proprietary Endosomal Escape Vehicle (EEV)™ platform, we are creating and advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently target and engage underlying drivers of diseases.

Our novel approach to drug design and delivery addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular biologics.

We're a tight-knit team of experts and leaders in both therapeutics development and rare disease and are excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Opportunity

  • Routinely support operation of large-scale solid-phase reactors
  • Learn the workflows of technical teams by shadowing lab scientists
  • Identify and/or optimize operations to improve process robustness, throughput, and cost while maintaining product quality
  • Assist with data management and assay analysis
  • Works towards future scalability
  • Provide mentorship to peers work toward an efficiently cross trained team

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drive our behavior: 

  • Humanity - We genuinely care about patients and about one another.
  • Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
  • Creativity - We are creative problem solvers.
  • Collaboration - We are more than the sum of our parts.
  • Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need :

  • Bachelors and/or masters in biochemistry, chemistry, chemical, or biological engineering, or a related discipline with 0‑2 years of relevant industry experience
  • Technical experience in the following areas is preferred: Solid-phase chemistry (peptides oligonucleotides, etc.), large-scale batch reactor operations, experimental design, assay development and troubleshooting.
  • Basic lab capabilities, such as pipetting and buffer preparation, are desired.
  • Prior co-op or internship experience is favorable.
  • Experience with analytical techniques (e.g. SEC, IEX, RP-HPLC, and LC-MS) for macromolecules such as RNA, DNA, and peptides will be plus.
  • Exceptional oral communication skills
  • Ability to effectively document and communicate results
  • Strong interpersonal skills with an eagerness to support colleagues across the organization and a demonstrated aptitude for team and employee development

You should be a naturally collaborative and a strong communicator, and let’s not forget the ability to multi-task effectively would be a huge plus in this fast-paced environment

The Perks

As a Contractor with Entrada, you will be eligible to participate in the Company’s transportation benefit and may expense up to $150 monthly for commuting purposes. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer. You will also be able to log Holiday hours to be paid for National Holidays.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.


Entrada Therapeutics is a biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines, Endosomal Escape Vehicle (EEV™) therapeutics, to engage intracellular targets that have long been considered inaccessible and undruggable. The Company’s EEV therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues with an improved therapeutic index. Through its proprietary, highly versatile and modular EEV platform, Entrada is building a robust development portfolio of oligonucleotide-, antibody- and enzyme-based programs for the potential treatment of neuromuscular diseases, immunology, oncology and diseases of the central nervous system. The Company’s lead oligonucleotide programs include ENTR-601-44 targeting Duchenne muscular dystrophy (DMD) and ENTR-701 targeting myotonic dystrophy type 1 (DM1).

Stock Symbol: TRDA
Stock Exchange: NASDAQ



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