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2023 Summer Internship - DMPK

San Diego, CA
Start date
Mar 17, 2023

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Science/R&D, Pharmacokinetics
Required Education
Bachelors Degree
Position Type
Full time
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Job Details

By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that the information I provide in my application will be processed in line with Takeda’s Privacy Notice and Terms of Use. I further attest that all information I submit in my employment application is true to the best of my knowledge.

Job Description

About the role:

At Takeda, we are committed to lifelong learning.

To that end, Takeda's summer internship program blends real world experience with an extensive overview of the pharmaceutical industry. Knowledgeable mentors will provide guidance as you gain professional hands-on experience to start your career or further develop in your expertise.

The summer internship program is a full-time commitment of 12 weeks in length and offers a unique perspective into a world-class pharmaceutical company. Our internship program also provides you the opportunity to network with people at Takeda through various planned events and activities.

Project Outline:

Synthetic small interfering RNA (siRNA) therapeutics provide a unique modality designed to selectively target and degrade specific messenger RNA (mRNA) that are involved in relevant disease pathways. One of the benefits of this modality is that it allows for selective targeting of any mRNA based on the target sequence. Because siRNA therapeutics cannot reach the site of action directly by diffusion, they must rely on different delivery vehicles that require encapsulation in a lipid nanoparticle or conjugation to a ligand that can internalize in a tissue of interest. Takeda is currently pursuing several siRNA therapies and is in need of a reliable human efficacious dosing regimen prediction for this modality to support progression of these therapies to the clinic. While there are a few FDA-approved siRNA therapeutics, there is still a poor understanding of the translation of efficacious dosing regimen from discovery to the clinic. In part, this may be due to the fact that siRNA exposure has been shown to be dependent on route of administration and the rate of siRNA internalization, which may be species dependent.

To address this gap, Takeda’s DMPK group is searching for a highly motivated candidate, who will compile, integrate, and analyze proprietary and published in vitro, in vivo, and clinical data and leverage various modeling approaches to help inform our understanding of the pharmacokinetics (PK) and tissue distribution, uptake kinetics, and intracellular trafficking of siRNAs across species. The candidate will build a mathematical model that captures the effects of the route of administration and internalization on the overall exposure of siRNAs. This work will help to enable human PK projections from preclinical studies for first-in-human dose predictions. The candidate will be part of a working group comprised of members from DMPK and Quantitative Solutions to address the human dose prediction questions across various siRNA programs.

Location: San Diego (hybrid-on site work environment)

How you will contribute:
  • Deadline-driven with a high level of organizational and planning skills

  • Strong analytical, problem-solving, and oral and written communication skills

  • Ability to work well in teams, effectively manage projects, and present ideas clearly and concisely.

  • Global mindset to grow in a diverse work environment

  • Excellent communication and leadership skills

  • Expertise in mathematical modeling with MATLAB, python, R, or Julia

Requirements / Qualifications:

As stated above, Takeda is committed to lifelong learning opportunities. To that end, our internship program is open to currently enrolled students seeking early experiences and non-traditional candidates interested in making a career change and gaining new experience.

The requirements for these two groups of candidates are specified below:

Candidates currently enrolled at an accredited university:

  • Must be authorized to work in the US without sponsorship (i.e., Takeda will not sponsor interns)

  • Must be available to work full-time (40 hours/week), within core business hours (8 AM-5 PM), for a minimum of 12 weeks during the summer months

  • Minimum GPA 3.0/4.0

  • Undergraduate, Graduate, PhD, MD student with at least one year of university studies before internship

  • Return to university for at least one semester post-internship

  • Takeda does not provide student housing or housing stipends

Non-traditional candidates not currently enrolled at university:

  • Must be authorized to work in the US without sponsorship (i.e., Takeda will not sponsor interns)

  • Must be available to work full-time (40 hours/week), within core business hours (8 AM-5 PM), for a minimum of 12 weeks during the summer months

  • Must provide a cover letter explaining why you are seeking this internship, relevant experience that makes you a good candidate, and what you hope to achieve through the experience

    • Strong preference for non-traditional candidates with some experience relevant to the desired intern role

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.


San Diego, CA

Worker Type


Worker Sub-Type

Paid Intern (Fixed Term) (Trainee)

Time Type

Full time


Takeda is a global, values-based, R&D-driven biopharmaceutical leader headquartered in Japan, committed to discover and deliver life-transforming treatments, guided by our commitment to patients, our people and the planet. Takeda focuses its R&D efforts on four therapeutic areas: Oncology, Rare Genetics and Hematology, Neuroscience, and Gastroenterology (GI). We also make targeted R&D investments in Plasma-Derived Therapies and Vaccines. We are focusing on developing highly innovative medicines that contribute to making a difference in people’s lives by advancing the frontier of new treatment options and leveraging our enhanced collaborative R&D engine and capabilities to create a robust, modality-diverse pipeline. Our employees are committed to improving quality of life for patients and to working with our partners in health care in approximately 80 countries and regions.

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Stock Symbol: TAK

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