Associate Director, Pathology Sciences

The Role:

Moderna is seeking a highly motivated Associated Director in the Pathology Sciences department for a position based at the Cambridge, MA site. The individual will lead a team of scientists and research associates, will be able to deliver in key scientific expertise in investigative pathology/toxicology and in this role, will help support Modernas mRNA technology platform, therapeutics area ventures, and partners by developing and performing routine and specialized in vitro assays for target validation, biomarker discovery, activity screens and investigative pathology/toxicology studies. The individual will help develop hypotheses for potential or identified toxicities and work in collaborative manner to develop and conduct in vitro and/or in vivo studies to elucidate potential mechanisms and proposed follow up strategies. Novel methodologies will be developed internally, and the group will partner with external collaborators, academic labs and CROs to ensure access to the latest technologies. The successful candidate will also need to interpret and analyze data, identify technical issues, recommend solutions, and communicate results to all levels of employees. In addition, the individual will help to achieve department objectives by managing Research associates, Post Doc fellows and Scientists; recruiting, selecting, and training employees. We are looking for a scientist with an incredibly deep toolset to solve problems facing a vast field of new modalities.

Heres What Youll Do:

• Create novel experimental designs for mechanistic pathology/toxicology studies designed to assess hypotheses for and evaluate mechanisms of toxicity related to physiological or biochemical functions

• Lead a team and contribute to hypotheses generation and drive the science for toxicology issue resolution in drug discovery and development.

• Use cutting edge molecular and cellular technologies to help make the next generation of gene and cell therapies. Broad expertise in novel molecular and cellular technologies including next-generation sequencing (NGS), organ-on-a-chip technology and other tissue models.

• Probe molecular and cellular mechanisms of toxicity to determine drivers of liver, cardiovascular and other toxicities and guide project teams on safety endpoints

• Communicate results clearly and concisely in both oral and written reports. Exhibit excellent oral and written communication skills.

• Perform in depth pathway/network analysis on data derived from toxicology and other studies.

• Collaborate with project team members and peers to anticipate and resolve day-to-day issues working in a matrix organizational structure.

Heres What Youll Bring to the Table:

• MS with 10+ years relevant industry experience.

• Familiar with drug discovery and development processes in investigative and regulatory toxicology.

Preferred Qualifications

• PhD with 5+ years relevant industry experience.

• Experience in conducting experimental pathology/toxicology in vitro studies highly desirable

Competencies

• Experience with conventional and advanced cell culture.

• Experience working with new modalities - including gene, cell, nanoparticle, and/or microbial therapeutics is highly desirable.

• Experience working in a matrixed team environment at a pharmaceutical company and/or CRO is essential.

• Broad scientific knowledge including pharmacology, toxicology, pathology, physiology, and biochemistry.

• Expertise designing & delivering fit for purpose assays for understanding the mechanism of toxicity of agents including drugs, for biomarker development and application, and for de-risking drug candidates.

• Effective communication (written and oral)

• Ability to work independently and as part of cross-functional teams

• Outcome-oriented and attentive to detail with strong analytical skills

• Ability to adapt to frequent change

• Strong multi-tasking and time-management skills

• Flexibility in responding to unexpected demands

• Superior problem-solving abilities

• Ability to work in a collaborative team environment

• Experience in managing scientists and demonstrate leadership skills

Moderna is pleased to provide you and your family with a comprehensive and innovative suite of benefits, including:

• Highly competitive and inclusive medical, dental and vision coverage options
• Flexible Spending Accounts for medical expenses and dependent care expenses
• Lifestyle Spending Account funds to help you engage in personal enrichment and self-care activities
• Family care benefits, including subsidized back-up care options and on-demand tutoring
• Free premium access to fitness, nutrition, and mindfulness classes
• Exclusive preferred pricing on Peloton fitness equipment
• Adoption and family-planning benefits
• Dedicated care coordination support for our LGBTQ+ community
• Generous paid time off, including:
  Vacation, sick time and holidays
  Volunteer time to participate within your community
  Discretionary year-end shutdown
  Paid sabbatical after 5 years; every 3 years thereafter
• Generous Paid Leave offerings, including 18 weeks of 100% paid parental leave for all new parents
• 401k match and Financial Planning tools
• Moderna-paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
• Complimentary concierge service including home services research, travel booking, and entertainment requests
• Free parking or subsidized commuter passes
• Location-specific perks and extras!

Candidates should be aware that Moderna currently maintains a policy requiring all US-based employees to be fully vaccinated against COVID-19 and receive a booster shot once eligible. Newly hired employees must be vaccinated and boosted prior to their employment start date. Moderna is an equal opportunity employer and will provide a reasonable accommodation to those unable to be vaccinated or receive a booster where it is not an undue hardship to the company to do so as provided under federal, state, and local law.

About Moderna

In over 10 years since its inception, Moderna has transformed from a research-stage company advancing programs in the field of messenger RNA (mRNA), to an enterprise with a diverse clinical portfolio of vaccines and therapeutics across seven modalities, a broad intellectual property portfolio in areas including mRNA and lipid nanoparticle formulation, and an integrated manufacturing plant that allows for rapid clinical and commercial production at scale. Moderna maintains alliances with a broad range of domestic and overseas government and commercial collaborators, which has allowed for the pursuit of both groundbreaking science and rapid scaling of manufacturing. Most recently, Moderna's capabilities have come together to allow the authorized use and approval of one of the earliest and most effective vaccines against the COVID-19 pandemic.

Moderna's mRNA platform builds on continuous advances in basic and applied mRNA science, delivery technology and manufacturing, and has allowed the development of therapeutics and vaccines for infectious diseases, immuno-oncology, rare diseases, cardiovascular diseases and autoimmune diseases. Moderna has been named a top biopharmaceutical employer by Science for the past seven years. To learn more, visit www.modernatx.com.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Moderna will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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