Scientist II (AAV Engineering)

Title: Scientist II (AAV Engineering) Manager: Senior Scientist
Department: Research (CNS) 
Location: Brisbane, CA

Sangamo Therapeutics is a genomic medicine company building value with cutting-edge work across four distinct but complementary technology platforms – gene therapy, cell therapy, in vivo genome editing, and in vivo genome regulation. Using its deep scientific expertise and proprietary zinc finger genome engineering technology, Sangamo is working to create genomic cures for patients suffering from severe genetic diseases for which today's medicines can only treat symptoms. At Sangamo, we are passionate about transforming lives by building a robust, sustainable, differentiated, innovative, and high value genomic medicine pipeline that addresses patients with life-limiting conditions. Sangamo takes pride in being the first to edit endogenous human genes, first to treat patients with gene edited T cells, and first to treat patients with in vivo genome editing. Our top priority is to meet the needs of patients with commitment and compassion. Along with our commitment to science and to our patients, we also endeavor to create an inclusive environment that promotes and values diversity. Sangamo is a company where individuals can flourish, grow and develop their expertise.
 
We are seeking top talent to join our mission. Let's build a better future together.

JOB SUMMARY:   
Sangamo Therapeutics is seeking a talented Scientist II to join our Research group and support the development of novel adeno-associated viruses (AAV) with improved delivery properties. The successful candidate will contribute to the advancement of therapeutics across our pipeline and in supporting the translation of research efforts into the clinic. The position requires adaptability, organization, attention to detail, and a capacity for constant innovation in pursuit of company goals. 


ESSENTIAL FUNCTIONS: 

• Advance the development of novel AAV capsids for targeted gene delivery to a variety of tissue targets with special emphasis on the central nervous system 
• Independently design and execute experiments to characterize the biological properties of AAV serotypes  
• Generate innovative solutions to overcome technical challenges in gene delivery 
• Manage and support research studies with partners and/or contract research organizations 
• Present results internally to R&D and executive leadership teams and externally at scientific conferences 
• Collaborate closely with members of the discovery, technology, delivery and nonclinical teams 
• Publish results in leading scientific journals and contribute to related patent filings

EDUCATION, EXPERIENCE AND SKILLS REQUIREMENTS:

• Ph.D. in Bioengineering, Neuroscience, Chemical Engineering, Virology, or related discipline 
• Expertise in protein engineering with demonstrated ability in high-throughput engineering initiatives 
• General understanding of drug delivery modalities including AAV 
• Experience in next generation sequencing and high throughput library screening  
• Expert in molecular biology techniques including cloning and quantitative PCR 
• Proficiency in mammalian cell culture 
• Expertise in neuroscience and blood-brain barrier biology is preferred 
• Experience in gene therapy is preferred 
• Bioinformatics and Python experience is a plus 
• Experience with robotics and automation is a plus 
• Familiarity with molecular modeling is a plus 
• Familiarity with immunohistochemistry and image analysis techniques is a plus

OTHER QUALIFICATIONS:

• Exceptional oral and written communication skills 
• Strong interpersonal skills 
• Ability to train and mentor research associates 
• Dedicated, hard-working, and dependable 

Sangamo is an equal opportunity employer
Sangamo is committed to fostering belonging for all employees and embraces diversity, equity, and inclusion in recruiting and hiring.  All qualified applicants for employment are encouraged to apply and will be considered without regard to an individual's race, color, sex, gender identity, gender expression, religion, age, national origin or ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws

Commitment to Safety
Sangamo requires all U.S. workers to be fully vaccinated against COVID-19 as of their start date.  This requirement is a condition of employment at Sangamo, and it applies regardless of location or classification of role.  If you are unable to receive the vaccine & booster, you will have an opportunity to request a reasonable accommodation consistent with applicable laws.    Pay Range The anticipated salary range is for candidates who will work in our Brisbane or Point Richmond, CA offices. The final salary offered to a successful candidate will be dependent on several factors that may include but, are not limited to, the type and length of experience with the job, type and length of experience within the industry, education, etc.  This salary range may not apply to remote positions that work in other states.
Note to External Recruiters: We do not accept unsolicited resumes from any source other than from the candidates themselves. If you wish to be considered for the presentation of candidates, please email recruiting@sangamo.com. We will reach out to you directly if there is a business need for your services.
 
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