Summer Lab Intern - Protein Sciences Group
- Emeryville, CA
- Start date
- Mar 14, 2023
- Science/R&D, Research, Laboratory
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Biotech Bay
We have an exciting Summer Lab Intern opportunity in our Protein Sciences group. This is a 10-12 week hands-on summer Internship located at our Headquarters in Emeryville, California. The Intern will contribute to the overall platform to assess the developability of antibodies which include colloidal stability, thermal stability, and purity using chemical fluorescent assays.
You will also work on improving the high throughput expression of antibodies using different vectors to compare expression levels. Traditionally, IgG are expressed using separate vectors for the heavy and light chain. This project would use a bicistronic vector to express the whole IgG using only one vector. As a result, the high throughput expression and purification protocol for IgG would be greatly improved.
OmniAb consists of dynamic and innovative scientists that employ a variety of novel platforms to support our partners in discovering next generation therapeutics. At the core of OmniAb is the ability to engineer animals to generate affinity matured human sequence antibodies for use in conventional and novel therapeutic formats. We leverage our proprietary animals with state-of-the-art technology in antigen design, immunization methods and high-throughput single B cell screening to facilitate discovery of best-in-class antibodies. Within OmniAb are also best-in-class capabilities for the discovery and screening in high value ion channel and transporter targets. We are looking for accomplished team players who are enthusiastic to contribute to the technological frontier of drug discovery, contribute to improving human health, and passionate in their desire to collaborate with partners to develop next generation therapeutics. See OmniAb.com for more details about the exciting science being performed at OmniAb.
This summer you will:
Learn to culture bacterial and mammalian cells
Learn a variety of antibody characterization techniques, with an emphasis on antibody self-association (colloidal stability)
Learn the high throughput expression and purification of IgGs, which would allow for the transfection of IgG with a singular plasmid rather than two, greatly reducing the workflow
Be trained in many of the common molecular biology techniques, including cloning, DNA transformation and purification
Have ample opportunities to use a variety of instruments for high throughput DNA purification and protein purification
Have plenty of opportunities to step away from the bench at least once a week to discuss weekly goals and ensure a proper understanding of the lab techniques and scientific principles being covered
Current Undergrad or Masters; Masters preferred in Biochemistry, Biology, Immunology
Must be 18 years or older to apply
Ability to multitask, and work in a fast-paced environment
Ability to work independently and as part of a team
Excellent interpersonal skills
All new hires are required to go through background checks
OmniAb is an EEO/AA/Disability/Vets employer
Must be legally authorized to work in the US without sponsorship
OmniAb celebrates the diversity of life and welcomes all individuals to apply
New hires & Interns based in the US will be required to demonstrate that they have been fully vaccinated and boosted for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement
Please Note: Intern will be responsible for all transportation costs, housing, and personal health insurance
Base Pay Range: $25 - $40/per hour
The pay range provided is an estimated base range for this role. Exact compensation may vary based on skills, experience, education level, and location.
OmniAb, Inc. is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.
OmniAb, Inc.’s discovery platform provides pharmaceutical industry partners access to diverse antibody repertoires and high-throughput screening technologies to enable discovery of next-generation therapeutics. At the heart of the OmniAb platform is the Biological Intelligence™ (BI) of our proprietary transgenic animals, including OmniRat®, OmniChicken® and OmniMouse® that have been genetically modified to generate antibodies with human sequences to facilitate development of human therapeutic candidates. OmniFlic® (transgenic rat) and OmniClic® (transgenic chicken) address industry needs for bispecific antibody applications though a common light chain approach, and OmniTaur™ features unique structural attributes of cow antibodies for complex targets.
We believe the OmniAb animals comprise the most diverse host systems available in the industry and they are optimally leveraged through computational antigen design and immunization methods, paired with high-throughput single B cell phenotypic screening and mining of next-generation sequencing datasets with custom algorithms to identify fully human antibodies with superior performance and developability characteristics.
An established core competency focused on ion channels and transporters further differentiates our technology and creates opportunities in emerging target classes. OmniAb antibodies have been leveraged across modalities, including bispecific antibodies, antibody-drug conjugates and others.
The OmniAb suite of technologies span from BI-powered repertoire generation to cutting edge antibody discovery and optimization offering a highly efficient and customizable end-to-end solution for the growing discovery needs of the global pharmaceutical industry.
5980 Horton Street
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