Senior Medical Director

Thank you for your interest in a career at Senti Biosciences. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases in ways previously inconceivable. We are passionate about designing gene circuits to improve the “intelligence” of cell and gene therapies in order to enhance their therapeutic effectiveness against a broad range of diseases that conventional medicines are unable to address.
 
At Senti, we find purpose and meaning knowing that our efforts have the potential to improve the lives of patients and their families with more effective and safer treatment options. With science as our foundation and empathy as our key guiding principle, colleagues become friends, managers become mentors, and with time, cancer becomes history.

Summary: The (Senior) Medical Director will initially report to the Chief Medical and Developmental Officer. This person will be accountable for developing and driving the Clinical Development strategy of individual products in alignment with the overall portfolio strategy of Senti Biosciences. 

The (Senior) Medical Director applies clinical therapeutic area and scientific knowledge, along with drug development experience to ensure the clinical program and individual studies can address clinical unmet need / improve the current standard of care for target oncology indications.The ( Senior) Medical Director will be responsible for interacting  with and maintaining excellent relationships both with external Investigators as well as with internal Senti experts to assure the swift identification of new early development opportunities to continuously optimize and refine the Development strategy. Together with key stakeholders, the (Senior) Medical Director will determine the clinical development plan that supports key deliverables and timely go-no go decisions to the next stage of development. In addition, for products with an approved IND, the individual serves as the product team lead. This individual is accountable for the seamless execution of project deliverables by working closely with the project manager and key stakeholders from across various functions in the company. The individual will be responsible for endorsing and integrating line function strategies, and is the single point of accountability for the seamless execution of program deliverables and decisions of the asset.
Responsibilities:

• Oversees clinical portfolio development from pre-IND onwards
• Acts as a medical director for assigned studies including conducting ongoing reviews of medical/safety data; collaborates with others in development of clinical documents adhering to ICH/GCP, including protocols,  investigator brochures, presentations and other materials; collaborates with others in development of study analytics and data management plans; participates in investigator and other external presentations, meetings and other communications
• Oversee the design  and execution of clinical trials that clearly meet the trial objectives, oversee patient safety as well as ensuring high quality data is obtained in a timely manner
• Collaborates with relevant teams and other groups to measure and monitor study progress against objectives and plans, including any variances, and proactively communicate any issues, challenges and potential strategies to resolve ; acts as point of contact and project representative to portfolio team/ to enable decision-making, including information dissemination and the resolution of critical project issues
• Serves as the team’s champion by negotiating and influencing key internal stakeholders
• Creates a motivated, committed and engaged project team
• Models and expects effective team behavior to achieve the project goals
• May support clinical operations, clinical research organizations (CROs), etc. by acting as a point-of-contact for questions, other communications, and interactions; identifying investigators and sites
• Establishes cross-functional relationships with leaders from key cross-functional lines: Regulatory Affairs, Clinical Operations, Program Management, etc.
• Leverages those relationships to manage key interdivisional interfaces on project issues including but not limited to Research, Development, Manufacturing and Competitive Intelligence
• Promotes a culture of innovation in order to bring forward creative development plans that maximize the potential of the asset
• Leverages functional line expertise to achieve the team goals
• Collaborates with others to ensure consistency of processes across Senti

Qualifications:

• Medical degree required
• Advanced training in oncology is preferred
• Cell and gene therapy experience will be a plus
• Minimum of 5-10 years (title commensurate with experience) of relevant clinical research experience in the pharmaceutical, or biotechnology companies having successfully executed a major component of a development program(s) such as reaching a go/no-go decision, closing a study and writing a CSR, interactions with health authorities, etc
• Strong understanding of all the elements of oncology drug development preclinical and clinical programs and experience in their design and execution
• Demonstrated experience in review, filing and defense of IND's, CTA's and full dossiers
• Demonstrated experience in successfully leading teams: 1) Running them effectively, efficiently and on target in alignment with Departmental and Corporate goals and budgets. 2) Capable of recognizing when team interventions are required to enhance team effectiveness
• Knowledgeable of the Commercial and Environmental issues that drive drug development projects
• Demonstrated experience working in a matrix environment in a biotechnology or pharmaceutical company
• Demonstrated experience in GXP (especially GCP, GLP) and experience working in a regulated

Salary and Benefits:

• Compensation for this role includes base salary, annual target bonus and equity
• The base salary range for this role is $XXX-XXX. Starting pay is determined by multiple job-related factors including a candidate’s skills, education and experience level, benchmark, and internal parity
• Significant growth opportunity as the company expands
• Empathetic, supportive and collaborative colleagues and work environments

Senti Bio is a publicly traded (Nasdaq: SNTI) gene circuit company headquartered in South San Francisco. Our mission is to create a new generation of smarter medicines that outmaneuver complex diseases using novel and unprecedented approaches.

We are committed to an inclusive and diverse Senti Bio. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse Senti Team. We welcome people of different backgrounds, experiences, abilities and perspectives and are an equal opportunity employer.