Scientist, Medicinal Chemistry

Alumis Inc is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients.

We are looking for an experienced Scientist who will be responsible for contributing toward the delivery of novel small molecules.

RESPONSIBILITIES

• The individual will be responsible for the design and synthesis of new small molecules for the potential treatment of immune-mediated diseases.
• The individual will apply modern techniques in organic chemistry and utilize current medicinal chemistry practices to solve problems.
• The individual will be expected to perform laboratory-based experiments, assist with laboratory instrument and equipment maintenance, and assure quality data capture and record keeping through an electronic laboratory notebook (ELN).
• The individual will be part of interdisciplinary project teams, requiring collaboration with computational chemists, biologists, and ADME colleagues to understand and contribute solutions to pressing problems faced by the project teams.
• The individual will interact with external resources including the proposal, oversight, and prioritization of new small molecule targets.

THE IDEAL CANDIDATE

• Candidates must have experience in designing and executing multistep synthesis of complex organic molecules using modern techniques in organic chemistry
• A knowledge base of medicinal chemistry principles including factors that influence ADME and physicochemical properties is desirable.
• Candidates should have expertise in the purification and characterization of organic compounds (silica gel chromatography, NMR, LCMS, HPLC)
• Excellent problem-solving skills and a thorough understanding of synthetic methods and reaction mechanisms are desirable
• Familiarity with chemical drawing programs (i.e. ChemDraw) and chemistry literature searching software (i.e. ReAxys, SciFinder) to design and plan synthetic routes
• Good oral/written communication skills and organizational skills with the desire to work and contribute to a collaborative team environment are required

EDUCATION

• Candidates must have a Ph.D. in organic chemistry with an additional 0-5 years of related industrial synthetic/medicinal-chemistry research experience OR an M.S. in organic chemistry with 5-10 years of related experience.

Alumis Values
• We Elevate
• We Challenge
• We Nurture

This position is located in South San Francisco, CA. At this time, we are not considering remote applicants.

The salary range for this position is $116,000 USD to $ 145,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

Alumis Inc. is an equal opportunity employer. If you are hired, we will require you to prove that you have received the primary series of an FDA-approved or authorized COVID -19 vaccine and at least one booster or have a valid religious or medical reason not to be vaccinated.